EVALUATION OF OXIDATIVE STRESS MARKERS AND LIPID PROFILE IN TYPE 2 DIABETES MELLITUS PATIENTS IN LAGOS- NIGERIA

Type 2 diabetes is an endocrine disease connected to some metabolic remodelings characterized by high blood glucose levels (hyperglycemia). However, the irregular occurrence of free radical generation, due to the oxidation of glucose, oxidative degradation of glycated proteins and protein nonenzymatic glycation; foster the advancement of type 2 diabetes. This study aims in comparing the correspondence between oxidative stress markers and lipid profiles of type 2 diabetes mellitus patients and non-diabetes persons. A total of 35 patients with type 2 diabetes and 36 persons as the control groups were examined by evaluating the plasma concentrations of some levels of biochemical parameters such as protein, total cholesterol (TC), triglycerides and high-density lipoprotein (HDL). The Plasma phospholipaseA2 (PA2) level was evaluated, as well as pro-oxidant indicators [malondialdehyde – MDA and nitric oxide (NO)] and oxidative status [superoxide dismutase (SOD), reduced glutathione level (GSH) and glutathione-S- transferase (GST)]; all analyzed using a standard spectrophotometric technique. The results indicated higher levels of MDA, GSH and GST in type 2 diabetic patients in contrast to non-diabetic control, however, MDA level of activity was significant. There was depletion in the levels of SOD and NO, with a significant decrease in NO. The study also observed a significant decrease in the concentrations of Total cholesterol, triglycerides, HDL and a significant increase in plasma PA2. This study reveals markers of oxidative stress in type 2 diabetes compared to the non-diabetic healthy control group. The results of some oxidative stress markers correlate with lipid profile in reducing risks associated with diabetic dyslipidemia. The imbalance in the oxidative stress markers of type 2 diabetic patients reflects the importance of diagnostic and prognostic tools for the medical management of diabetes. They might be good indicators for the risk of complications