Background : Insulin-like growth factor I (IGF-I) is a polypeptide hormone produced mainly by the liver in response to the endocrine GH stimulus, but it is also secreted by multiple tissues for autocrine/paracrine purposes. IGF-I is partly responsible for systemic GH activities although it possesses a wide number of own properties (anabolic, antioxidant, anti-inflammatory and cytoprotective actions). IGF-I is a closely regulated hormone. Low IGF-1 level are observed in GH deficiency or GH resistence. If acquired in childhood, these condition result short stature. Currently the best characterized conditions of IGF-I deficiency are Laron Syndrome, in children; liver cirrhosis, in adults; aging including age-related-cardiovascular and neurolog...
Context and Objective: Main features of the autosomal dominant form of GH deficiency (IGHD II) inclu...
Background: Lysinuric protein intolerance (LPI; MIM# 222700) is a rare metabolic disorder caused by ...
Context: Small for gestational age (SGA)-born children comprise a heterogeneous group in which only ...
Endocrinology Context: Short stature in children is a common reason for referral to pediatric endocr...
Background: Severe primary insulin-growth factor-1 (IGF1) deficiency (SPIGF1D) is a rare cause of gr...
Item does not contain fulltextCONTEXT: Homozygous IGF1 deletions or mutations lead to severe short s...
Short stature in children is a common reason for referral to pediatric endocrinologists. The underly...
CONTEXT: Homozygous IGF1 deletions or mutations lead to severe short stature, deafness, microcephaly...
Context: Homozygous IGF1 deletions or mutations lead to severe short stature, deafness, microcephaly...
Context: Microscopically visible heterozygous terminal 15q deletions encompassing the IGF1R gene are...
Chromosome 15q26-qter deletion syndrome is a rare disease that causes prenatal and postnatal growth ...
While insensitivity to GH (GHI) is characterized by low IGF-I levels, normal or elevated GH levels, ...
Background: Growth failure and growth hormone deficiency (GHD) have been reported as one accessory f...
Context: The type 1 IGF-I receptor (IGF1R) mediates the biological functions of IGF-I. Binding of IG...
Our understanding of the IGF-I system has increased dramatically in recent yr due in part to the adv...
Context and Objective: Main features of the autosomal dominant form of GH deficiency (IGHD II) inclu...
Background: Lysinuric protein intolerance (LPI; MIM# 222700) is a rare metabolic disorder caused by ...
Context: Small for gestational age (SGA)-born children comprise a heterogeneous group in which only ...
Endocrinology Context: Short stature in children is a common reason for referral to pediatric endocr...
Background: Severe primary insulin-growth factor-1 (IGF1) deficiency (SPIGF1D) is a rare cause of gr...
Item does not contain fulltextCONTEXT: Homozygous IGF1 deletions or mutations lead to severe short s...
Short stature in children is a common reason for referral to pediatric endocrinologists. The underly...
CONTEXT: Homozygous IGF1 deletions or mutations lead to severe short stature, deafness, microcephaly...
Context: Homozygous IGF1 deletions or mutations lead to severe short stature, deafness, microcephaly...
Context: Microscopically visible heterozygous terminal 15q deletions encompassing the IGF1R gene are...
Chromosome 15q26-qter deletion syndrome is a rare disease that causes prenatal and postnatal growth ...
While insensitivity to GH (GHI) is characterized by low IGF-I levels, normal or elevated GH levels, ...
Background: Growth failure and growth hormone deficiency (GHD) have been reported as one accessory f...
Context: The type 1 IGF-I receptor (IGF1R) mediates the biological functions of IGF-I. Binding of IG...
Our understanding of the IGF-I system has increased dramatically in recent yr due in part to the adv...
Context and Objective: Main features of the autosomal dominant form of GH deficiency (IGHD II) inclu...
Background: Lysinuric protein intolerance (LPI; MIM# 222700) is a rare metabolic disorder caused by ...
Context: Small for gestational age (SGA)-born children comprise a heterogeneous group in which only ...