The effect of postmenopusal hormone replacement therapy on serum Lipoprotein (a) concentration

Obejctive : To evaluate whether postmenopusal hormone replacement therapy influences the plasma lipoprotein with special emphasis on lipoprotein (a). Methods : 60 postmenopusal women, who visited Yongdong severance hospitial were assesed. After a baseline study, conjugated equine estrogen(0.625mg) was given to 12 women(group A) and conjugated equine estrogen(0.625mg) plus medroxyprogesterone acetate (5mg) were given to 48 women(group B). Blood samples were obtained at 3 months and 5 months after therapy. Ruselts : Serum lipoprotein(a) concentration was not correlated with the age and the duration of menopause. Serum total cholesterol was decreased from 216.0+-13.8 mg/dl to 198.5+-6.9mg/dl at 5 months after therapyrestrictio