Clinical Significance of Expression of p53 gene and c-erbB-2 gene with Immunohistochemical Staining in Cervical Cancer

We investigated the diagnostic usefulness of the demonstration of p53 and c-erbB-2 immunoreactivity in cervical cancers, because immuno-histochemical demonstration of p53 immunoreactivity is inexpensive, easily controlled and can be applied in routine pathology laboratories. p53 and c-erbB-2 immunoreactivity was not identified in any patients in whom there was no morphological evidence of neoplasa. In contrast, in 73% of patients of cervical cancer, p53 immunoreactivity was identified, and in 23% of patients, c-erbB-2 was identified. Overexpression of p53 gene correlates with advanced stage and large sized lision, but c-erbB-2 does not correlate with any prognostic factor.restrictio