An Immunohistochemical Study of Estrogen and Progesterone Receptors in Laryngeal Intubation Grauuloma

With the development of techniques of anesthesia, the post-intubation laryngeal granuloma has been one of the sequelae of endotracheal intubation. Since the initial report of laryngeal intubation granuloma in 1932 by Clausen, a variety of etiologic factors have been described. The incidence has been more frequently reported in women than men, especially in women who has received Caesarean section, so it can be presumed cautiously that the female sex hormones possibly correlate with its pathogenesis. Unlike simple granulation tissues, laryngeal granulomas show histologic characteristics of capillary lobules separated by fibromyxoid stroma suggesting hemodynamic change, so sex hormonal correlation is further suspected. The authors studied the relationship of sex hormone to the pathogenesis intubation granuloma by immunohistochemical method using 14 cases of granuloma taken from surgery. We concluded that the female sex hormones play no roles in the pathogenesis of laryngeal intubation granuloma through our results in which the reaction pattern was non-specific regardless of the state of pregnancy or child-bearing age. However, more precise multi-factorial cross-correlation between sex hormones and the pathogenesis of laryngeal intubation granuloma study will be neccessery with collection of cases.ope