Application of MRI diffusion weighted imaging and perfusion weighted in primary and secondary brain tumor evaluation

Purpose: The aim of this study was to evaluate the contribution of DWI and PWI in the clinical practice precisely: in characterization and grading of brain gliomas, characterization and differential diagnosis of brain malignancies, discrimination between benign and malignant brain lesions, characterization of meningioma (Μ) and discrimination between regression (R) and post irradiation necrosis (PIN). Patients and Methods: Conventional 1.5 T MRI, DWI, and PWI were performed on total of 185 patients. 170 patients with intracranial malignancies [low grade astrocytoma (LGA), high grade astrocytoma (HGA), solitary brain metastases (SBM) and brain lymphomas (BL), 124 patients with benign lesions [M, brain abscesses (BA), encephalitis (E), tumefactive multiple sclerosis (TMS), arteriovenous malformations (AVM) and PRES] and 15 patients with R, PIN or combination. Τhe diagnosis was confirmed for brain malignancies and for the cases with regression and PIN with strereotactic biopsy or resection (subtotal or total) and for benign brain lesions with strereotactic biopsy or resection or analysis of cerebrospinal fluid and laboratory examinations. The Mann-Whitney U test and One-Way ANOVA or Kruskal-Wallis employed in order to identify statistical differences in mean ADCs and mean rCBVs rations in the regions of interest of the brain lesions. Results: The mean ADCs in the solid part were lower in high-grade gliomas (HGG) than low grade gliomas (LGG), but not statistical significantly p> 0.001. The mean rCBVs in the solid part were higher in HGG than low LGG and statistical significantly, p 0.001. The mean rCBVs the solid part was higher in R than PIN with p0.001 και υψηλότερη τιμή λόγου rCBV με p