Cell- and Tissue-Containing Biosensors

International audienceWhole cell biosensors allow detection of modifications of a cell or a microorganism used as an integrated system. Cells and tissues from prokaryotic to higher eukaryotic origins are used as standard biosensors with two main outputs, fluorescence and bioluminescence. These living systems can be used as biosensors per se. Alternatively, their properties can be transposed by molecular engineering to any desired cell model with many applications and benefits especially in terms of access to sophisticated and accurate detection modes. Looking ahead, new developments mainly concern transposition of whole cell biosensors to the human body for monitoring and diagnosis purposes