Background Recent studies have implicated variants of the transcription factor 7-like 2 (TCF7L2) gene in genetic susceptibility to type 2 diabetes mellitus in several different populations. The aim of this study was to determine whether variants of this gene are also risk factors for type 2 diabetes development in a UK-resident South Asian cohort of Punjabi ancestry. Methods We genotyped four single nucleotide polymorphisms (SNPs) of TCF7L2 (rs7901695, rs7903146, rs11196205 and rs12255372) in 831 subjects with diabetes and 437 control subjects. Results The minor allele of each variant was significantly associated with type 2 diabetes; the greatest risk of developing the disease was conferred by rs7903146, with an allelic odds ratio...
Background: Type 2 diabetes mellitus (T2DM) is the most prevalent component of metabolic syndrome. E...
Emerging evidence indicates that variation in the transcription factor 7-like 2 (TCF7L2) gene may pl...
Aims/hypothesis: The gene encoding transcription factor 7-like 2 (TCF7L2) has been identified as a t...
Background - Recent studies have implicated variants of the transcription factor 7-like 2 (TCF7L2) g...
Background: The variants of transcription factor 7-like 2 (TCF7L2) gene have been shown to be associ...
Recent data suggest that common variation in the transcription factor 7-like 2 (TCF7L2) gene is asso...
Recent data suggest that common variation in the transcription factor 7-like 2 (TCF7L2) gene is asso...
Aim/hypothesis A strong association between susceptibility to type 2 diabetes and common variants of...
Common variants in the transcription factor 7-like 2 (TCF7L2) gene have been associated with type 2 ...
Recent data suggest that common variation in the tran-scription factor 7-like 2 (TCF7L2) gene is ass...
Aim/hypothesis A strong association between susceptibility to type 2 diabetes and common variants of...
In various populations worldwide, common variants of the TCF7L2 (Transcription factor 7-like 2) gene...
Background: Type 2 diabetes mellitus (T2DM) is the most prevalent component of metabolic syndrome. E...
Emerging evidence indicates that variation in the transcription factor 7-like 2 (TCF7L2) gene may pl...
Aims/hypothesis: The gene encoding transcription factor 7-like 2 (TCF7L2) has been identified as a t...
Background - Recent studies have implicated variants of the transcription factor 7-like 2 (TCF7L2) g...
Background: The variants of transcription factor 7-like 2 (TCF7L2) gene have been shown to be associ...
Recent data suggest that common variation in the transcription factor 7-like 2 (TCF7L2) gene is asso...
Recent data suggest that common variation in the transcription factor 7-like 2 (TCF7L2) gene is asso...
Aim/hypothesis A strong association between susceptibility to type 2 diabetes and common variants of...
Common variants in the transcription factor 7-like 2 (TCF7L2) gene have been associated with type 2 ...
Recent data suggest that common variation in the tran-scription factor 7-like 2 (TCF7L2) gene is ass...
Aim/hypothesis A strong association between susceptibility to type 2 diabetes and common variants of...
In various populations worldwide, common variants of the TCF7L2 (Transcription factor 7-like 2) gene...
Background: Type 2 diabetes mellitus (T2DM) is the most prevalent component of metabolic syndrome. E...
Emerging evidence indicates that variation in the transcription factor 7-like 2 (TCF7L2) gene may pl...
Aims/hypothesis: The gene encoding transcription factor 7-like 2 (TCF7L2) has been identified as a t...