Add to ORKGDeveloping brain of mammals is organized by gonadal steroids during the critical period of sexual differentiation (E18-PN10). The regulatory role of neurosteroids in the early brain is unclear. It is known that 17-β-estradiol (E2) is produced within the brain itself primarily due to local aromatization of gonadal testosterone and also due to de novo synthesis from cholesterol. Little is known about the circulating and local levels of steroids in the embryonic brain. Thus, the use of animal models that dissociate the effect of gonadal sex from sex chromosomes heritage facilitates the study of organizational actions of gonadal steroids and neurosteroids in each sex.http://www.saneurociencias.org.ar/congreso-2014/Fil: Cisternas, Carla Dan...
Sex steroid action is critical to form sexually dimorphic nuclei, although it is not fully understoo...
Sex steroid action is critical to form sexually dimorphic nuclei, although it is not fully understoo...
Aromatase is the enzyme responsible for converting testosterone to estradiol. In mammals, aromatase ...
The brain is a steroidogenic tissue. It expresses key molecules involved in the synthesis and metabo...
Aromatase, which converts testosterone in estradiol, is involved in the generation of brain sex dimo...
The brain is a steroidogenic tissue. It expresses key molecules involved in the synthesis and metabo...
During development sex differences in aromatase expression in limbic regions of mouse brain depend o...
Female mouse hippocampal and hypothalamic neurons growing in vitro show a faster development of neur...
Aromatase cytochrome P450 enzyme catalyzes the formation of estrogen from androgen in distinct regio...
A growing body of evidences indicates that some sexually dimorphic traits cannot be solely explained...
Estrogen synthesized in situ in the CNS by the enzyme aromatase plays an important role during brain...
In mammals, the reproductive function is controlled by the hypothalamic-pituitary-gonadal axis. Duri...
Female mouse hippocampal and hypothalamic neurons growing in vitro show a faster development of neur...
Gonadal steroid hormones are neurotrophic and neuroprotective. These effects are modulated by local ...
When steroids, such as pregnenolone, progesterone and oestrogen, are synthesised de novo in neural t...
Sex steroid action is critical to form sexually dimorphic nuclei, although it is not fully understoo...
Sex steroid action is critical to form sexually dimorphic nuclei, although it is not fully understoo...
Aromatase is the enzyme responsible for converting testosterone to estradiol. In mammals, aromatase ...
The brain is a steroidogenic tissue. It expresses key molecules involved in the synthesis and metabo...
Aromatase, which converts testosterone in estradiol, is involved in the generation of brain sex dimo...
The brain is a steroidogenic tissue. It expresses key molecules involved in the synthesis and metabo...
During development sex differences in aromatase expression in limbic regions of mouse brain depend o...
Female mouse hippocampal and hypothalamic neurons growing in vitro show a faster development of neur...
Aromatase cytochrome P450 enzyme catalyzes the formation of estrogen from androgen in distinct regio...
A growing body of evidences indicates that some sexually dimorphic traits cannot be solely explained...
Estrogen synthesized in situ in the CNS by the enzyme aromatase plays an important role during brain...
In mammals, the reproductive function is controlled by the hypothalamic-pituitary-gonadal axis. Duri...
Female mouse hippocampal and hypothalamic neurons growing in vitro show a faster development of neur...
Gonadal steroid hormones are neurotrophic and neuroprotective. These effects are modulated by local ...
When steroids, such as pregnenolone, progesterone and oestrogen, are synthesised de novo in neural t...
Sex steroid action is critical to form sexually dimorphic nuclei, although it is not fully understoo...
Sex steroid action is critical to form sexually dimorphic nuclei, although it is not fully understoo...
Aromatase is the enzyme responsible for converting testosterone to estradiol. In mammals, aromatase ...