4-Hydroxycoumarins constitute the structural nucleus of many natural products, drugs, and pesticides. Promising biological properties in new families of synthetic coumarins were recently reported. Therefore, efficient synthesis of new benzopyrano[3,2-c]chromene-6,8-dione was undertaken and the structures of 15 compounds were confirmed by their IR, Mass, H-1-NMR, and C, H, N analysis. Then, the cytotoxic activities of these compounds were assessed on four different human cancer cell lines (Raji, HeLa, LS180, and MCF-7). The results showed that these compounds had weak-to-moderate antitumoral activities and their IC50 ranged from 49 to more than 100 mu M. Among the compounds 9,10-dihydro-7-(3-methoxyphenyl)-7H,11H-benzopyrano[3,2-c]chromene-6...
Coumarins are a large family of natural and synthetic compounds exerting different pharmacological ...
Novel fused chromenes (4,7–11) and pyrimidines (12–16) were designed, synthesized, and e...
Cancer is at present one of the most leading causes of death in the developed countries, and many ef...
Coumarins are naturally occurring oxygen heterocyclic compounds having multifarious medicinal proper...
Cancer is one of the important health problems, and researchers continue their efforts to discover n...
Benzopyran (chromene) is one of the privileged medicinal pharmacophore, which appears as an importan...
Cancer is a major cause of death worldwide and novel anticancer agents for its better management are...
AbstractThe chemical class of benzopyrones consists of a large number of compounds possessing the be...
Coumarins are extensively studied anticoagulants that exert additional effects such as anticanceroge...
In this work, 3-bromoacetylcoumarin was used as the key starting material for the synthesis of pyran...
In this work, 3-bromoacetylcoumarin was used as the key starting material for the synthesis of pyran...
We report on the synthesis of 4-hydroxycoumarin dimers 1-15 bearing an aryl substituent on the centr...
The newly synthesized coumarin derivative with dopamine, 3-(1-((3,4-dihydroxyphenethyl)amino)ethylid...
© 2019 Dušan S. Dimić et al. The newly synthesized coumarin derivative with dopamine, 3-(1-((3,4-di...
Abstract Background Coumarin (...
Coumarins are a large family of natural and synthetic compounds exerting different pharmacological ...
Novel fused chromenes (4,7–11) and pyrimidines (12–16) were designed, synthesized, and e...
Cancer is at present one of the most leading causes of death in the developed countries, and many ef...
Coumarins are naturally occurring oxygen heterocyclic compounds having multifarious medicinal proper...
Cancer is one of the important health problems, and researchers continue their efforts to discover n...
Benzopyran (chromene) is one of the privileged medicinal pharmacophore, which appears as an importan...
Cancer is a major cause of death worldwide and novel anticancer agents for its better management are...
AbstractThe chemical class of benzopyrones consists of a large number of compounds possessing the be...
Coumarins are extensively studied anticoagulants that exert additional effects such as anticanceroge...
In this work, 3-bromoacetylcoumarin was used as the key starting material for the synthesis of pyran...
In this work, 3-bromoacetylcoumarin was used as the key starting material for the synthesis of pyran...
We report on the synthesis of 4-hydroxycoumarin dimers 1-15 bearing an aryl substituent on the centr...
The newly synthesized coumarin derivative with dopamine, 3-(1-((3,4-dihydroxyphenethyl)amino)ethylid...
© 2019 Dušan S. Dimić et al. The newly synthesized coumarin derivative with dopamine, 3-(1-((3,4-di...
Abstract Background Coumarin (...
Coumarins are a large family of natural and synthetic compounds exerting different pharmacological ...
Novel fused chromenes (4,7–11) and pyrimidines (12–16) were designed, synthesized, and e...
Cancer is at present one of the most leading causes of death in the developed countries, and many ef...