Add to ORKGImpaired mucociliary clearance may increase COPD exacerbation risk. We aimed to compare bronchial ciliary function and epithelial ultrastructure of COPD patients to healthy controls and explore its relationship to exacerbator phenotypes (frequent [FE] and infrequent [IFE] exacerbator). In this cross-sectional study, 16 COPD patients and 12 controls underwent bronchial brushings. Ciliary beat frequency (CBF) and dyskinesia index (DI; % of dyskinetic cilia) were assessed using digital high-speed video microscopy, and epithelial ultrastructure using transmission electron microscopy (TEM). Bronchial epithelium in COPD showed lower CBF and higher DI, compared to controls (median [IQR] CBF: 6.8 (6.1–7.2) Hz vs 8.5 (7.7–8.9) Hz, p<0.001 and DI: 73...
Background: Mucociliary clearance(MCC) results in an effective interaction between the mucus layer a...
Although ciliary dysfunction and numerous ultrastructural defects have been described, and these cou...
In COPD, epithelial changes are prominent features in the airways, such as goblet cell hyperplasia a...
Impaired mucociliary clearance may increase COPD exacerbation risk. We aimed to compare bronchial ci...
Chronic obstructive pulmonary disease (COPD) is a frequent respiratory disease. However, its pathoph...
SummaryCOPD is characterized by increased cough, mucus production, and airway inflammation. Beating ...
10.1080/15412555.2021.1963695COPD: Journal of Chronic Obstructive Pulmonary Disease1806657-66
<div><p>Smoking and COPD are associated with decreased mucociliary clearance, and healthy smokers ha...
Smoking and COPD are associated with decreased mucociliary clearance, and healthy smokers have short...
Whereas cilia damage and reduced cilia beat frequency have been implicated as causative of reduced m...
BACKGROUND:Whereas cilia damage and reduced cilia beat frequency have been implicated as causative o...
The objective of the study: to compare the state of mucociliary clearance and bronchial ciliated epi...
Airway epithelium is the first line of defense against exposure of the airway and lung to various in...
Introduction. Some studies have found that cilia were shorter in COPD smokers than in nonsmokers or ...
Rationale: In chronic obstructive pulmonary disease (COPD), epithelial changes are prominent feature...
Background: Mucociliary clearance(MCC) results in an effective interaction between the mucus layer a...
Although ciliary dysfunction and numerous ultrastructural defects have been described, and these cou...
In COPD, epithelial changes are prominent features in the airways, such as goblet cell hyperplasia a...
Impaired mucociliary clearance may increase COPD exacerbation risk. We aimed to compare bronchial ci...
Chronic obstructive pulmonary disease (COPD) is a frequent respiratory disease. However, its pathoph...
SummaryCOPD is characterized by increased cough, mucus production, and airway inflammation. Beating ...
10.1080/15412555.2021.1963695COPD: Journal of Chronic Obstructive Pulmonary Disease1806657-66
<div><p>Smoking and COPD are associated with decreased mucociliary clearance, and healthy smokers ha...
Smoking and COPD are associated with decreased mucociliary clearance, and healthy smokers have short...
Whereas cilia damage and reduced cilia beat frequency have been implicated as causative of reduced m...
BACKGROUND:Whereas cilia damage and reduced cilia beat frequency have been implicated as causative o...
The objective of the study: to compare the state of mucociliary clearance and bronchial ciliated epi...
Airway epithelium is the first line of defense against exposure of the airway and lung to various in...
Introduction. Some studies have found that cilia were shorter in COPD smokers than in nonsmokers or ...
Rationale: In chronic obstructive pulmonary disease (COPD), epithelial changes are prominent feature...
Background: Mucociliary clearance(MCC) results in an effective interaction between the mucus layer a...
Although ciliary dysfunction and numerous ultrastructural defects have been described, and these cou...
In COPD, epithelial changes are prominent features in the airways, such as goblet cell hyperplasia a...