PEGylation markedly enhances the in vivo potency of recombinant human non-glycosylated erythropoietin: A comparison with glycosylated erythropoietin
- Wang, Yin-Jue
- Hao, Su-Juan
- Liu, Yong-Dong
- Hu, Tao
- Zhang, Gui-Feng
- Zhang, Xuan
- Qi, Qing-Sheng
- Ma, Guang-Hui
- Su, Zhi-Guo
- Liu, YD
Publication date
August 2010
DOI Publisher
Elsevier BV ISSN
0168-3659 Citation count (estimate)
40Abstract
Recombinant human non-glycosylated erythropoietin (rh-ngEpo) expressed in E. coli was attached to polyethylene glycol (PEG) chains with different sizes and structures. The pharmacokinetic properties and in vivo potency of the PEGylated protein were investigated and comparisons were drawn between the conjugates and glycosylated recombinant Epo (rhEpo)
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