MOBSTER is an approach for subclonal reconstruction of tumors from cancer genomics data on the basis of models that combine machine learning with evolutionary theory, thus leading to more accurate evolutionary histories of tumors
Many cellular models aimed at elucidating cancer biology do not recapitulate pathobiology including ...
Variant allele frequencies (VAF) encode ongoing evolution and subclonal selection in growing tumours...
Whole-genome sequencing can be used to estimate subclonal populations in tumours and this intra-tumo...
15siMost cancer genomic data are generated from bulk samples composed of mixtures of cancer subpopul...
Abstract The vast majority of cancer next-generation sequencing data consist of bulk samples compose...
Tumor DNA sequencing data can be interpreted by computational methods that analyze genomic heterogen...
Methods for reconstructing tumor evolution are benchmarked in the DREAM Somatic Mutation Calling Tum...
Subclonal reconstruction from bulk tumor DNA sequencing has become a pillar of cancer evolution stud...
4siBackground. The large-scale availability of whole-genome sequencing profiles from bulk DNA sequen...
Tumours are composed of multiple subpopulations, each of which has its own genotype and phenotype. ...
<div><p>Recent improvements in next-generation sequencing of tumor samples and the ability to identi...
Cancer is a complex and deadly disease that is caused by genetic lesions in somatic cells. Further r...
Cancer is an evolutionary process driven by somatic mutations that accumulate in a population of cel...
Most cancers evolve from a single founder cell through a series of clonal expansions that are driven...
BackgroundNext-generation sequencing (NGS) panels for mature B-cell neoplasms (MBNs) are widely appl...
Many cellular models aimed at elucidating cancer biology do not recapitulate pathobiology including ...
Variant allele frequencies (VAF) encode ongoing evolution and subclonal selection in growing tumours...
Whole-genome sequencing can be used to estimate subclonal populations in tumours and this intra-tumo...
15siMost cancer genomic data are generated from bulk samples composed of mixtures of cancer subpopul...
Abstract The vast majority of cancer next-generation sequencing data consist of bulk samples compose...
Tumor DNA sequencing data can be interpreted by computational methods that analyze genomic heterogen...
Methods for reconstructing tumor evolution are benchmarked in the DREAM Somatic Mutation Calling Tum...
Subclonal reconstruction from bulk tumor DNA sequencing has become a pillar of cancer evolution stud...
4siBackground. The large-scale availability of whole-genome sequencing profiles from bulk DNA sequen...
Tumours are composed of multiple subpopulations, each of which has its own genotype and phenotype. ...
<div><p>Recent improvements in next-generation sequencing of tumor samples and the ability to identi...
Cancer is a complex and deadly disease that is caused by genetic lesions in somatic cells. Further r...
Cancer is an evolutionary process driven by somatic mutations that accumulate in a population of cel...
Most cancers evolve from a single founder cell through a series of clonal expansions that are driven...
BackgroundNext-generation sequencing (NGS) panels for mature B-cell neoplasms (MBNs) are widely appl...
Many cellular models aimed at elucidating cancer biology do not recapitulate pathobiology including ...
Variant allele frequencies (VAF) encode ongoing evolution and subclonal selection in growing tumours...
Whole-genome sequencing can be used to estimate subclonal populations in tumours and this intra-tumo...