Clinical characterization of Post-axial Polydactyly

Polydactyly is among the most common congenital limb malformations, presenting at an estimated incidence of 1 in approximately 700–1,000 live births. Clinical manifestation of polydactyly remains poorly understood because of their phenotypic variabilities and genetic diversity. Prenatal ultrasound screening can detect polydactyly and can alert the health care worker and the pregnant woman to proceed with further anomaly screening to exclude possible concomitant anomalies The aim of this review is to provide an overview of the genetic basis of non-syndromic post axial polydactyly(PAP) and discuss the role of biological pathways in non-syndromic PAP to help clinicians understand and characterize the disease