Add to ORKGA series of phenyl piperidine α-sulfone hydroxamate derivatives has been prepared utilizing a combination of solution-phase and resin-bound library technologies to afford compounds that are potent and highly selective for MMP-13, are dual-sparing of MMP-1 and MMP-14 (MT1-MMP) and exhibit oral bioavailability in rats
Osteoarthritis (OA) is the leading cause of joint pain and disability in middle-aged and elderly pat...
Table of Contents ACKNOWLEDGEMENTS 3 SUMMARY......... 8 SAMENVATTING 10 LIST OF ABBREVIATIONS 13 G...
Matrix metalloproteinases (MMPs) are a family of zinc dependent endopeptidases known to play key rol...
A series of N-aryl isonipecotamide α-sulfone hydroxamate derivatives has been prepared utilizing a c...
Continuing our interest in designing compounds preferentially potent and selective for MMP-13, we re...
α-Sulfone-α-piperidine and α-tetrahydropyranyl hydroxamates were explored that are potent inhibitors...
A series of α-amino-β-sulphone hydroxamates was prepared and evaluated for potency versus MMP-13 and...
Seeking compounds preferentially potent and selective for MMP-13, we reported in the preceding Lette...
A series of α-alkyl-α-amino-β-sulphone hydroxamates was prepared and evaluated for potency versus MM...
Matrix metalloproteinase 7 (MMP-7) is a member of the MMP superfamily and is able to degrade extrace...
α-Piperidine-β-sulfone hydroxamate derivatives were explored that are potent for matrix metalloprote...
This letter describes SAR exploration and rat PK optimization of a series of novel, MMP-1 sparing ar...
Osteoarthritis (OA) is the leading cause of joint pain and disability in middle-aged and elderly pat...
A novel series of sulfone N-formylhydroxylamines (retrohydroxamates) have been investigated as matri...
We describe the characterisation of a series of 4,4'-biphenylsulfonamides as selective inhibitors of...
Osteoarthritis (OA) is the leading cause of joint pain and disability in middle-aged and elderly pat...
Table of Contents ACKNOWLEDGEMENTS 3 SUMMARY......... 8 SAMENVATTING 10 LIST OF ABBREVIATIONS 13 G...
Matrix metalloproteinases (MMPs) are a family of zinc dependent endopeptidases known to play key rol...
A series of N-aryl isonipecotamide α-sulfone hydroxamate derivatives has been prepared utilizing a c...
Continuing our interest in designing compounds preferentially potent and selective for MMP-13, we re...
α-Sulfone-α-piperidine and α-tetrahydropyranyl hydroxamates were explored that are potent inhibitors...
A series of α-amino-β-sulphone hydroxamates was prepared and evaluated for potency versus MMP-13 and...
Seeking compounds preferentially potent and selective for MMP-13, we reported in the preceding Lette...
A series of α-alkyl-α-amino-β-sulphone hydroxamates was prepared and evaluated for potency versus MM...
Matrix metalloproteinase 7 (MMP-7) is a member of the MMP superfamily and is able to degrade extrace...
α-Piperidine-β-sulfone hydroxamate derivatives were explored that are potent for matrix metalloprote...
This letter describes SAR exploration and rat PK optimization of a series of novel, MMP-1 sparing ar...
Osteoarthritis (OA) is the leading cause of joint pain and disability in middle-aged and elderly pat...
A novel series of sulfone N-formylhydroxylamines (retrohydroxamates) have been investigated as matri...
We describe the characterisation of a series of 4,4'-biphenylsulfonamides as selective inhibitors of...
Osteoarthritis (OA) is the leading cause of joint pain and disability in middle-aged and elderly pat...
Table of Contents ACKNOWLEDGEMENTS 3 SUMMARY......... 8 SAMENVATTING 10 LIST OF ABBREVIATIONS 13 G...
Matrix metalloproteinases (MMPs) are a family of zinc dependent endopeptidases known to play key rol...