Add to ORKGContinuing our interest in designing compounds preferentially potent and selective for MMP-13, we report on a series of hydroxamic acids with a flexible amide P1\u27 substituents. We identify an amide which spares both MMP-1 and -14, and shows \u3e500 fold selectivity for MMP-13 versus MMP-2 and -8
This is a pre-publication author manuscript of the final, published article. This Article is brought...
Matrix metalloproteinases (MMPs) are a family of zinc dependent endopeptidases known to play key rol...
My Thesis project was focused on the study of new ADAMs and MMPs synthetic inhibitors. ADAMs and MMP...
Seeking compounds preferentially potent and selective for MMP-13, we reported in the preceding Lette...
Continuing our interest in designing compounds preferentially potent and selective for MMP-13, we re...
A series of N-aryl isonipecotamide α-sulfone hydroxamate derivatives has been prepared utilizing a c...
A series of α-amino-β-sulphone hydroxamates was prepared and evaluated for potency versus MMP-13 and...
A series of phenyl piperidine α-sulfone hydroxamate derivatives has been prepared utilizing a combin...
A series of α-alkyl-α-amino-β-sulphone hydroxamates was prepared and evaluated for potency versus MM...
Matrix metalloproteinase 7 (MMP-7) is a member of the MMP superfamily and is able to degrade extrace...
The matrix metalloproteinase enzyme MMP-13 plays a key role in the degradation of type II collagen i...
Osteoarthritis (OA) is the leading cause of joint pain and disability in middle-aged and elderly pat...
SummaryInhibitors for matrix metalloproteinases (MMPs) are under investigation for the treatment of ...
Osteoarthritis (OA) is the leading cause of joint pain and disability in middle-aged and elderly pat...
Matrix metalloproteinase-13 (MMP-13) is a key enzyme implicated in the degradation of the extracellu...
This is a pre-publication author manuscript of the final, published article. This Article is brought...
Matrix metalloproteinases (MMPs) are a family of zinc dependent endopeptidases known to play key rol...
My Thesis project was focused on the study of new ADAMs and MMPs synthetic inhibitors. ADAMs and MMP...
Seeking compounds preferentially potent and selective for MMP-13, we reported in the preceding Lette...
Continuing our interest in designing compounds preferentially potent and selective for MMP-13, we re...
A series of N-aryl isonipecotamide α-sulfone hydroxamate derivatives has been prepared utilizing a c...
A series of α-amino-β-sulphone hydroxamates was prepared and evaluated for potency versus MMP-13 and...
A series of phenyl piperidine α-sulfone hydroxamate derivatives has been prepared utilizing a combin...
A series of α-alkyl-α-amino-β-sulphone hydroxamates was prepared and evaluated for potency versus MM...
Matrix metalloproteinase 7 (MMP-7) is a member of the MMP superfamily and is able to degrade extrace...
The matrix metalloproteinase enzyme MMP-13 plays a key role in the degradation of type II collagen i...
Osteoarthritis (OA) is the leading cause of joint pain and disability in middle-aged and elderly pat...
SummaryInhibitors for matrix metalloproteinases (MMPs) are under investigation for the treatment of ...
Osteoarthritis (OA) is the leading cause of joint pain and disability in middle-aged and elderly pat...
Matrix metalloproteinase-13 (MMP-13) is a key enzyme implicated in the degradation of the extracellu...
This is a pre-publication author manuscript of the final, published article. This Article is brought...
Matrix metalloproteinases (MMPs) are a family of zinc dependent endopeptidases known to play key rol...
My Thesis project was focused on the study of new ADAMs and MMPs synthetic inhibitors. ADAMs and MMP...