The study aims to identify the main challenges in the applicability of interprofessional education in the context of Primary Health Care. It is an integrative literature review with a qualitative approach, guided by the following research question “What are the main difficulties encountered in the applicability of interprofessional education in the context of Primary Health Care?”. Data collection took place between September and October in the Latin American and Caribbean Literature and Health Sciences, Databases in Nursing and Scientific Electronic Library Online databases. For the search strategy, the descriptors in Health Sciences (DECS) were used, being “Interprofessional Education”, “Primary Health Care” and “Patient Assistance Team”....