The Sickle Cell Anemia (SCA) is an inherited disease characterized by homozygous severe hemolytic anemia and clinical variables, considered a chronic inflammatory disease. SCA results from a mutation in a nitrogenous base in the sixth codon of the beta globin gene, leading to substitution of adenine for thymine nucleotide (GAG → GTG), which results in the production of the amino acid valine in place of glutamic acid. The inflammatory pathophysiology of SCA is centered on the ability of HbS polymerization that leads to chronic hemolysis and vaso-occlusion. SCA patients are a chronic inflammatory state of multifactorial origin that involves endothelial cells, erythrocytes, leukocytes and platelets by increasing the interactions between cell-c...
Dissertação de mestrado em Genética Molecular e Biomedicina apresentada à Faculdade de Ciências e Te...
Sickle cell disease is a chronic inflammatory condition characterized by elevated levels of inflamma...
A anemia falciforme (AF) Ã uma doenÃa hereditÃria resultante de uma mutaÃÃo pontual (GAG  GT...
AbstractThe chronic inflammatory state in sickle cell anemia (SCA) is associated with several factor...
Sickle cell anemia (SCA) is caused by a point mutation leading the substitution of glutamic acid for...
ABSTRACTBackgroundSickle cell anemia is a chronic inflammatory disease characterized by an increased...
Introduction: Sickle cell anemia (SCA) hereditary hemoglobinopathy in homozygosis of the S allele (...
Hematopoietic stem cell transplantation (HSCT) has emerged as a curative strategy for sickle cell an...
Introduction: Sickle cell anaemia (SCA) is a clinically heterogeneous autosomal recessive monogenic ...
texto completo: acesso restrito. p. 312–317.Sickle cell anemia (SCA) is a disorder characterized by ...
Sickle cell disease (SCD) is a hematological disease caused by a point mutation in the β-globin gene...
Sickle cell anemia (SCA) shows a pathophysiology that involves multiple changes in sickle cell eryth...
Embora a anemia falciforme (AF) resulte da homozigosidade de uma única mutação, no codon 6 do locus ...
FCT / Aga Khan Development Network (project “SCAFfoldChild” nº 330842553).Sickle Cell Anemia (SCA) i...
Introduction: Sickle cell anemia (SCA) is one of the most common genetic disorders in the world. How...
Dissertação de mestrado em Genética Molecular e Biomedicina apresentada à Faculdade de Ciências e Te...
Sickle cell disease is a chronic inflammatory condition characterized by elevated levels of inflamma...
A anemia falciforme (AF) Ã uma doenÃa hereditÃria resultante de uma mutaÃÃo pontual (GAG  GT...
AbstractThe chronic inflammatory state in sickle cell anemia (SCA) is associated with several factor...
Sickle cell anemia (SCA) is caused by a point mutation leading the substitution of glutamic acid for...
ABSTRACTBackgroundSickle cell anemia is a chronic inflammatory disease characterized by an increased...
Introduction: Sickle cell anemia (SCA) hereditary hemoglobinopathy in homozygosis of the S allele (...
Hematopoietic stem cell transplantation (HSCT) has emerged as a curative strategy for sickle cell an...
Introduction: Sickle cell anaemia (SCA) is a clinically heterogeneous autosomal recessive monogenic ...
texto completo: acesso restrito. p. 312–317.Sickle cell anemia (SCA) is a disorder characterized by ...
Sickle cell disease (SCD) is a hematological disease caused by a point mutation in the β-globin gene...
Sickle cell anemia (SCA) shows a pathophysiology that involves multiple changes in sickle cell eryth...
Embora a anemia falciforme (AF) resulte da homozigosidade de uma única mutação, no codon 6 do locus ...
FCT / Aga Khan Development Network (project “SCAFfoldChild” nº 330842553).Sickle Cell Anemia (SCA) i...
Introduction: Sickle cell anemia (SCA) is one of the most common genetic disorders in the world. How...
Dissertação de mestrado em Genética Molecular e Biomedicina apresentada à Faculdade de Ciências e Te...
Sickle cell disease is a chronic inflammatory condition characterized by elevated levels of inflamma...
A anemia falciforme (AF) Ã uma doenÃa hereditÃria resultante de uma mutaÃÃo pontual (GAG  GT...