Development of high-resolution tandem mass spectrometer with floated collision cell and curved-field reflectron.

Li, Gang.Thesis (M.Phil.)--Chinese University of Hong Kong, 2008.Includes bibliographical references (leaves 102-108).Abstracts in English and Chinese.TABLE OF CONTENTS --- p.vLIST OF FIGURES --- p.viiiLIST OF TABLES --- p.xiABBREVIATIONS --- p.xiiChapter Chapter One --- IntroductionChapter 1.1 --- Matrix-assisted Laser Desorption/Ionization (MALDI) --- p.2Chapter 1.1.1 --- Laser Desorption --- p.2Chapter 1.1.2 --- Matrix-assisted Laser Desorption/Ionization --- p.2Chapter 1.2 --- Time-of-flight Mass Spectrometry --- p.6Chapter 1.2.1 --- Linear Time-of-flight Mass Spectrometer --- p.6Chapter 1.2.2 --- Reflectron Time-of-flight Mass Spectrometer --- p.7Chapter 1.2.2.1 --- Linear-field Reflectron --- p.9Chapter 1.2.2.2 --- Nonlinear-field Reflectron --- p.12Chapter 1.3 --- Structural Analysis Using Time-of-flight Mass Spectrometer --- p.13Chapter 1.4 --- Project Objectives --- p.17Chapter Chapter Two --- Instrumentation and ExperimentalChapter 2.1 --- Instrumentation --- p.20Chapter 2.1.1 --- Laser system --- p.20Chapter 2.1.2 --- Flight Tube and Vacuum System --- p.20Chapter 2.1.3 --- Ion source --- p.22Chapter 2.1.4 --- Deflector and Time Ion Selector --- p.24Chapter 2.1.5 --- Two-stage Gridless Reflectron --- p.28Chapter 2.1.6 --- "Detectors, Digitizer and Computer System" --- p.28Chapter 2.2 --- Experimental --- p.31Chapter 2.2.1 --- Sample preparation --- p.32Chapter 2.2.2 --- PSD calibration --- p.32Chapter Chapter Three --- "Simulation Studies of Time Ion Selector, Collision cells and Curved-field Reflectron"Chapter 3.1 --- Introduction --- p.35Chapter 3.2 --- Time Ion selector --- p.37Chapter 3.3 --- Collision cell --- p.46Chapter 3.3.1 --- Simulation of Collision Induced Dissociation (CID) Conditions --- p.46Chapter 3.3.2 --- Design and Performance Evaluation of Different Collision Cells --- p.48Chapter 3.4 --- Curved-field reflectron (CFR) --- p.58Chapter 3.4.1 --- Introduction --- p.58Chapter 3.4.2 --- Derivation of Analytical Equations --- p.58Chapter 3.4.3 --- Effect of Floating Potential of the Collision Cell --- p.65Chapter 3.4.4 --- Effect of R and θ Parameters --- p.65Chapter 3.4.5 --- Effect of Length of the Reflectron --- p.70Chapter 3.5 --- Conclusions --- p.73Chapter Chapter Four --- Construction and Performance Evaluation of Modified Time-of-flight Mass SpectrometerChapter 4.1 --- Benchmark Results for the Origin Reflectron Time-of-flight Mass Spectrometer --- p.75Chapter 4.2 --- Hardware Modifications of Reflectron Time-of-flight Mass Spectrometer --- p.75Chapter 4.2.1 --- Collision Cell --- p.75Chapter 4.2.2 --- Curved-field Reflectron --- p.79Chapter 4.3 --- Evaluation of the Curved-field Reflectron --- p.81Chapter 4.4 --- Evaluation of the field-shaped cylindrical collision cell --- p.85Chapter 4.5 --- Conclusions --- p.95Chapter Chapter Five --- Concluding RemarksChapter 5.1 --- Concluding Remarks --- p.100References --- p.101AppendixAppendix 1 User program for time ion selection --- p.108Appendix 2 User program for gas collision --- p.111Appendix 3 MATHEMATICA program used in calculation for curved-fleld reflectron --- p.11