Synthetic studies of zoapatanol: construction of the oxepane system by intramolecular nitrile oxide and/or nitrone cycloaddition.

by Ching-hung Wong.Thesis (M.Phil.)--Chinese University of Hong Kong, 1993.Includes bibliographical references (leaves 75-78).Chapter i --- BiographyChapter ii --- AbstractChapter iii --- AcknowledgmentsChapter iv --- AbberivationsChapter Chapter 1 --- IntroductionChapter 1.1 --- Review on the published syntheses of Zoapatanol --- p.1Chapter 1.2 --- Review on the construction of the oxepane ring --- p.7Chapter 1.3 --- "Review on the intramolecular nitrone and nitrile oxide 1,3-dipolar cycloaddition" --- p.15Chapter 1.3.a. --- Nitrone-olefin cycloaddition --- p.16Chapter 1.3.b. --- Nitrile-oxide-olefin cycloaddition --- p.17Chapter 1.4 --- Isoxazoline Transformation --- p.18Chapter Chapter 2 --- Results and DiscussionChapter 2.1 --- General Aspect --- p.19Chapter 2.2 --- "Entries to 6 and 7-membered O-heterocycles via 1,3-dipolar nitrone cycloaddition" --- p.21Chapter 2.3 --- "Entries to 6 and 7-membered O-heterocycles via l,，3-diploar nitrile oxide cycloaddition" --- p.33Chapter 2.4 --- Conclusion --- p.47Chapter Chapter 3 --- ExperimentalGeneral --- p.49Experimental --- p.51References --- p.7