Molecular mechanisms involved in induction of cell growth arrest and cell death in human colon cancer cells by tangutorine, a b-carboline.

Liu Bonnie Pui-ling.Thesis (M.Phil.)--Chinese University of Hong Kong, 2004.Includes bibliographical references (leaves 134-163).Abstracts in English and Chinese.Acknowledgments --- p.iAbbreviations --- p.iiAbstractEnglish --- p.1Chinese --- p.3Chapter Chapter 1 --- General IntroductionChapter 1.1 --- Colorectal Cancer Statistics --- p.5Chapter 1.2 --- Colon Cancer --- p.5Chapter 1.3 --- Treatment --- p.6Chapter 1.4 --- Effects of Cytotoxic Drug Treatment --- p.7Chapter 1.5 --- Cell Cycle --- p.8Chapter 1.6 --- Oxidases --- p.9Chapter 1.7 --- Chemistry of Novel β-carboline: Tangutorine --- p.11Chapter 1.8 --- Aim of Study --- p.14Chapter Chapter 2 --- CytotoxicityChapter 2.1 --- Introduction --- p.15Chapter 2.2 --- Materials and Methods --- p.18Chapter 2.3 --- Results --- p.23Chapter 2.4 --- Discussion --- p.44Chapter Chapter 3 --- Oxidase Activity and Protein OxidationChapter 3.1 --- Introduction --- p.48Chapter 3.2 --- Materials and Methods --- p.54Chapter 3.3 --- Results --- p.60Chapter 3.4 --- Discussion --- p.80Chapter Chapter 4 --- Cell CycleChapter 4.1 --- Introduction --- p.89Chapter 4.2 --- Materials and Methods --- p.93Chapter 4.3 --- Results --- p.96Chapter 4.4 --- Discussion --- p.118Chapter Chapter 5 --- General Discussion --- p.126References --- p.13