Treatment of inoperable hepatocellular carcinoma: from systemic to regional, from conventional to novel.

by Wai-Tong Leung.Thesis (M.D.)--Chinese University of Hong Kong, 1995.Includes bibliographical references (leaves 282-315).Title Page --- p.iDedication --- p.iiTable of Contents --- p.iiiPrecis to the thesis --- p.7Glossary of abbreviation used in the thesis --- p.20List of Figures and Pictures --- p.22List of Tables --- p.26Acknowledgments --- p.30Statement of Originality --- p.32Chapter PART ONE --- IntroductionChapter Chapter 1 --- Background for Hepatocellular CarcinomaChapter 1. --- History --- p.33Chapter 2. --- "Epidemiology - World wide, China,Hong Kong" --- p.36Chapter 3. --- Pathology --- p.55Chapter 4. --- Aetiology --- p.62Chapter 5. --- Clinical Manifestation and Diagnosis --- p.68Chapter 6. --- Natural History --- p.74Chapter 7. --- Conventional Treatment --- p.76Chapter 8. --- Prognosis --- p.85Chapter Chapter 2 --- Hepatocellular Carcinoma in Hong KongChapter 1. --- Clinical Study of 1119 cases of Hepatocellular Carcinoma --- p.88Chapter PART TWO --- Conventional Treatment for Hepatocellular CarcinomaChapter Chapter 3 --- Chemotherapy for Hepatocellular CarcinomaChapter 1. --- Review of the Literature in Systemic Chemotherapy --- p.108Chapter 2. --- Phase II Trials of Systemic Chemotherapy --- p.114Chapter a. --- VP16-213 --- p.115Chapter b. --- Low Dose 4'-Epidoxorubicin --- p.116Chapter c. --- High Dose 4'-Epidoxorubicin --- p.117Chapter d. --- 5_FU and High Dose Folinic Acid --- p.119Chapter e. --- High Dose Ifosfamide --- p.122Chapter 3. --- Review of the Literature in Intra-Arterial Chemotherapy --- p.125Chapter 4. --- Intra-Arterial Chemotherapy Trial Performed in PWH --- p.131Chapter a. --- An Early Phase II Trial on Treatment of Inoperable Hepatocellular Carcinoma by Intrahepatic Arterial Chemotherapy with Lipiodol and 4'-Epidoxorubicin --- p.131Chapter b. --- "Phase II Trial of Treatment of Inoperable Hepatocellular Carcinoma by Intra-Arterial Lipiodol and High Dose 4'-Epidoxorubicin, a Comparison with Intravenous 4'-Epidoxorubicin" --- p.137Chapter PART THREE --- Novel Treatment for Hepatocellular CarcinomaChapter Chapter 4 --- Selective Internal Radiation Treatment for Hepatocellular CarcinomaChapter 1. --- Review of the Literature in Radiotherapy for Liver Tumours --- p.145Chapter 2. --- Selective Internal Radiation with 131Iodine-Lipiodol in HCCChapter a. --- Background and Review of the Literature --- p.151Chapter b. --- Physical Aspects of 131Iodine-Lipiodol --- p.154Chapter c. --- Bio-distribution of 131I-L in one HCC Patient --- p.156Chapter d. --- Clinical Study on the Use of131I-Lipiodol in the Treatment of Inoperable HCC --- p.168Chapter 3. --- Selective Internal Radiation with 90Yttrium-Microspheres in HCCChapter a. --- Background and Review of the Literature --- p.182Chapter b. --- Physical Aspects of 90Yttrium-Microspheres --- p.187Chapter c. --- Treatment of Inoperable Hepatocellular Carcinoma with Intrahepatic-Arterial 90Yttrium Microspheres - An Early Phase II Study --- p.195Chapter d. --- Treatment of Inoperable Hepatocellular Carcinoma with Intrahepatic-arterial 90Yttrium Microspheres through Hepatic Angiography --- p.214Chapter 4. --- Selection of Patients for 90Yttrium -Microspheres Treatment --- p.230Chapter a. --- Diagnostic Scintigraphy with Hepatic Intra-Arterial Technetium-99m Macroaggregated Albumin in the Determination of Tumour to Non-Tumour Uptake Ratio in Hepatocellular Carcinoma --- p.230Chapter b. --- Measuring Lung Shunting in Hepatocellular Carcinoma with Intrahepatic-Arterial Technetium-99m Macroaggregated Albumin Scan --- p.245Chapter c. --- Correlation of Tumour Vascularity Grading by Selective Hepatic Angiography with T/N Ratio from Tc-MAA Scanin Hepatocellular Carcinoma --- p.260Chapter d. --- Pulmonary Complications from 90Yttrium-Microspheres Treatment --- p.266Conclusion of the Thesis --- p.280References to Chapter1 --- p.282References to Chapter2 --- p.296References to Chapter3 --- p.297References to Chapter4 --- p.308Appendix:Chapter 1. --- Recommendations for Grading of Acute and Subacute Toxicityin Cancer Treatment --- p.316Chapter 2. --- Recommendations for Grading of Response Criteria --- p.318Selected Publications by the Author Relevant to the Thesis --- p.31