Pre-surgical mood disorders associated to worse post-surgical seizure outcome in patients with refractory temporal lobe epilepsy and mesial temporal sclerosis

Araújo Filho,Gerardo Maria de
Gomes,Francinaldo Lobato
Mazetto,Lenon
Marinho,Murilo Martinez
Tavares,Igor Melo
Caboclo,Luís Otávio Sales Ferreira
Yacubian,Elza Márcia Targas
Centeno,Ricardo Silva

Open link

Publication date

March 2012

DOI

10.1590/S1676-26492012000100006

Publisher

FapUNIFESP (SciELO)

Abstract

OBJECTIVES: This study aims at verifying the impact of pre-surgical PD on seizure outcome in patients with refractory temporal lobe epilepsy and mesial temporal sclerosis (TLE-MTS). METHODS: After previous consent, retrospective data from 115 surgically treated (corticoamygdalohyppocampectomy) TLE-MTS patients (65 females; 56.5%) were analyzed. Psychiatric evaluations were performed through DSM-IV criteria. Engel IA was established as a favorable prognosis. RESULTS: Forty-five patients (41.6%) were classified as Engel IA, while 47 (40.8%) presented pre-surgical PD. Depression (OR=5.11; p=0.004) appeared as a risk factor associated to a non-favorable seizure outcome. CONCLUSION: In patients with refractory TLE-MTS, the presence of depression...