Adherence to Treatment of Phenylketonuria: A Study in Southern Brazilian Patients
- Vieira,Tatiane Alves
- Nalin,Tatiéle
- Krug,Bárbara Correa
- Bittar,Camila Matzenbacher
- Oliveira Netto,Cristina Brinckmann
- Schwartz,Ida Vanessa Doederlein
DOIAbstract
Abstract Introduction: Phenylketonuria (PKU) is caused by the deficient activity of phenylalanine hydroxylase. Aim: To identify the factors associated with treatment adherence among patients with PKU seen at a southern Brazil reference center. Methodology: A cross-sectional, outpatient-based study including 56 patients with PKU (median age, 12 years) for whom a Phe-restrict diet plus specific metabolic formula have been prescribed. Patients were considered adherent or nonadherent depending on the median phenylalanine concentration for the 12 months prior to study and target levels of phenylalanine for each age range (<13 years = ≤360 µmol/L; ≥13 years = ≤900 µmol/L). Data were collected through a review of patient’s medical records and a...
Add to ORKG