Examination of recruitment of the Rad 1 - Rad 10 protein complex to sites of DNA double strand break repair, RAD1 genetic mutations in DNA nucleotide excision repair in Saccharomyces cerevisiae by fluorescence microscopy, and characterization of motor neuron types derived from human embryonic stem cells

Includes bibliographical references (leaves 51-55)Chapter I: Several DNA repair pathways exist including double strand break repair (DSBR) and nucleotide excision repair (NER), that employ a cohort of protein factors which are recruited based on the type of damage present and other variables. Damage causing breaks through both strands of the DNA helix are repaired by DSBR sub-pathways, homologous recombination (HR) and non-homologous end-joining (NHEJ). Repair of UV and select chemically induced les ions in DNA is carried out by nucleotide excision repair (NER). (See more in text.