Effect of shRNA-based knockdown of btg1 on glucocorticoid-evoked cell cycle arrest and apoptosis of CEM-C7-15 human leukemia cells

Includes bibliographical references (leaves 56-60)BTG 1 (B-cell Translocation Gene 1) has been identified as an anti-proliferative protein that has a role in G1 cell cycle arrest leading to T-lymphocyte cell apoptosis. The gene, btg1 has been previously shown by microarray analysis to be upregulated by glucocorticoids (GCs) in the GC-sensitive CEM-C7-14 cells and not in the GC-resistant sister clone CEM-Cl-15. This suggests btg1 is involved in the apoptosis signaling pathway induced by GCs. (See more in text.