Effects of phytohemagglutinins from phaseolus beans (P. vulgaris L.) on intestinal mucosa

Não consta resumo na publicaçãoBiological and immunological properties of phytohemagglutins from two brazilian varieties of beans (Phaseolus vulgaris) were studied. Through immunoprecipitation in agar gel, immuoenzymatic assays (ELISA) and eletrophoretic behavior after affinity chromatography purification it was shown that the lectins are similar. Both lectins when given to rats are toxic. They reduce growth and intestinal dissacharidase activity. They also able to smooth the \"microvillous\" of the enterocyte and to induce the appearance of autophagosomes in the enterocyte citoplasm. All this modification result in a reduced rate of carbohydrates absorption either in \"vitro\" or \"in vivo\"