In vitro adherence of Candida albicans isolated from patients with chronic periodontitis

Made available in DSpace on 2019-09-12T16:56:56Z (GMT). No. of bitstreams: 0 Previous issue date: 2011Adherence is considered an extremely important virulence factor in yeast. Objective: The aim of this study was to analyze the adherence to epithelial cells of C. albicans isolated from patients with chronic periodontitis in comparison to healthy patients. Material and methods: Candida albicans cells isolated from individuals with chronic periodontitis (n=25) and healthy controls (n=25) were included in this study. Suspensions of C. albicans (10(6) cells/rnL) and epithelial cells (10(5) cells/mL) were mixed and incubated at 37 degrees C for 1 h. The number of yeasts adhered to 25 epithelial cells was counted. Results: The number of C. albicans cells adhered to epithelial cells was statistically higher in the chronic periodontitis group than in the control group (Student's t-test, p=0.000). Conclusion: The results of the present study suggest a higher Candida adherence of samples isolated from patients with chronic periodontitis.[Koga-Ito, Cristiane Yumi] State Univ Sao Paulo, Dept Biosci & Oral Diag, Sao Jose dos Campos Dent Sch, UNESP, Sao Jose Dos Campos, SP, Brazil[Machado, Adriana Gadotti; Komiyama, Edson Yukio; Cardoso Jorge, Antonio Olavo; Brighenti, Fernanda Lourencao; Koga-Ito, Cristiane Yumi] State Univ Sao Paulo, Dept Biosci & Oral Diag, Sao Jose dos Campos Dent Sch, UNESP, Sao Jose Dos Campos, SP, Brazil[Ferreira dos Santos, Silvana Soleo] Universidade de Taubaté (Unitau) , Dept Dentistr