In vitro adherence of Candida albicans isolated from patients with chronic periodontitis

Made available in DSpace on 2019-09-12T16:32:39Z (GMT). No. of bitstreams: 0 Previous issue date: 2011Adherence is considered an extremely important virulence factor in yeast. OBJECTIVE: The aim of this study was to analyze the adherence to epithelial cells of C. albicans isolated from patients with chronic periodontitis in comparison to healthy patients. MATERIAL AND METHODS: Candida albicans cells isolated from individuals with chronic periodontitis (n=25) and healthy controls (n=25) were included in this study. Suspensions of C. albicans (10(6) cells/mL) and epithelial cells (10(5) cells/mL) were mixed and incubated at 37ºC for 1 h. The number of yeasts adhered to 25 epithelial cells was counted. RESULTS: The number of C. albicans cells adhered to epithelial cells was statistically higher in the chronic periodontitis group than in the control group (Student's t-test, p=0.000). CONCLUSION:The results of the present study suggest a higher Candida adherence of samples isolated from patients with chronic periodontitis.[Santos, Silvana Soléo Ferreira dos] Universidade de Taubaté, BrazilMachado, Adriana Gadotti; Komiyama, Edson Yukio; Jorge, Antonio Olavo Cardoso; Brighenti, Fernanda Lourenção; Koga-Ito, Cristiane Yumi] Universidade Estadual Paulista, Brazi