Endothelium-dependent vasorelaxing activity of aqueous extracts of lyophilized seeds of Casimiroa edulis (AECe) on rat mesenteric arterial bed

Submitted by Elisangela Pires (emotapires@gmail.com) on 2011-03-23T02:12:04Z No. of bitstreams: 1 Endothelium-dependent vasorelaxing activity of aqueous extracts of lyophilized seeds of (AE) on rat mesenteric arterial bed..pdf: 96852 bytes, checksum: 319fb9bf96c525f1c09a15c82067a1a1 (MD5)Approved for entry into archive by Barbara Milbrath(barbaramilbrath@yahoo.com.br) on 2011-03-23T17:21:28Z (GMT) No. of bitstreams: 1 Endothelium-dependent vasorelaxing activity of aqueous extracts of lyophilized seeds of (AE) on rat mesenteric arterial bed..pdf: 96852 bytes, checksum: 319fb9bf96c525f1c09a15c82067a1a1 (MD5)Made available in DSpace on 2011-03-23T17:21:28Z (GMT). No. of bitstreams: 1 Endothelium-dependent vasorelaxing activity of aqueous extracts of lyophilized seeds of (AE) on rat mesenteric arterial bed..pdf: 96852 bytes, checksum: 319fb9bf96c525f1c09a15c82067a1a1 (MD5) Previous issue date: 2004The vasorelaxing activity of the aqueous extracts of Casimiroa edulis seeds F(AECe) on mesenteric arterial bed (MAB) of rats was studied. MABprecontracted with methoxaminewas mounted on a tissue bath and exposed to plant extracts (bolus 50, 500, 2500 and 5000 g). The bolus injections of AECe significantly inhibited, in a concentration-dependent manner, the maximal contractile response induced by methoxamine (30 m) in MAB. After endothelium removal, the vascular ability of Casimiroa edulis aqueous extract was significantly changed. Treatment with an inhibitor of NO synthase (l-NOA, 10 M) also modified the AECe effect. The guanilate cyclase inhibitor methylene blue (MB, 100 M) inhibited the AECe-induced vasodilatation. These results suggest the involvement of NO of endothelial source (or related factors) in this vasodilator effect