Add to ORKGA panel of cell lines of diverse molecular background offers an improved model system for high-content screening, comparative analysis, and cell systems biology. A computational pipeline has been developed to collect images from cell-based assays, segment individual cells and colonies, represent segmented objects in a multidimensional space, and cluster them for identifying distinct subpopulations. While each segmentation strategy can vary for different imaging assays, representation and subpopulation analysis share a common thread. Application of this pipeline to a library of 41 breast cancer cell lines is demonstrated. These cell lines are grown in 2D and imaged through immunofluorescence microscopy. Subpopulations in this panel are ident...
Image-based cell profiling is a high-throughput strategy for the quantification of phenotypic differ...
<p>High content screening for drug discovery in cancer research relies increasingly on cell-based mo...
Organotypic, three dimensional (3D) cell culture models of epithelial tumour types such as prostate ...
A panel of cell lines of diverse molecular background offers an improved model system for high-conte...
The publication describes how, in many situations, 3D cell cultures mimic the natural organization o...
Correlative analysis of molecular markers with phenotypic signatures is the simplest model for hypot...
Background: High content screening techniques are increasingly used to understand the regulation and...
In many situations, 3D cell cultures mimic the natural organization of tissues more closely than 2D ...
Image-based cell profiling is a high-throughput strategy for the quantification of phenotypic differ...
In many situations, 3D cell cultures mimic the natural organization of tissues more closely than 2D ...
\u3cp\u3eImage-based cell profiling is a high-throughput strategy for the quantification of phenotyp...
Image-based cell profiling is a high-throughput strategy for the quantification of phenotypic differ...
Image-based cell profiling is a high-throughput strategy for the quantification of phenotypic differ...
Image-based cell profiling is a high-throughput strategy for the quantification of phenotypic differ...
Image-based cell profiling is a high-throughput strategy for the quantification of phenotypic differ...
Image-based cell profiling is a high-throughput strategy for the quantification of phenotypic differ...
<p>High content screening for drug discovery in cancer research relies increasingly on cell-based mo...
Organotypic, three dimensional (3D) cell culture models of epithelial tumour types such as prostate ...
A panel of cell lines of diverse molecular background offers an improved model system for high-conte...
The publication describes how, in many situations, 3D cell cultures mimic the natural organization o...
Correlative analysis of molecular markers with phenotypic signatures is the simplest model for hypot...
Background: High content screening techniques are increasingly used to understand the regulation and...
In many situations, 3D cell cultures mimic the natural organization of tissues more closely than 2D ...
Image-based cell profiling is a high-throughput strategy for the quantification of phenotypic differ...
In many situations, 3D cell cultures mimic the natural organization of tissues more closely than 2D ...
\u3cp\u3eImage-based cell profiling is a high-throughput strategy for the quantification of phenotyp...
Image-based cell profiling is a high-throughput strategy for the quantification of phenotypic differ...
Image-based cell profiling is a high-throughput strategy for the quantification of phenotypic differ...
Image-based cell profiling is a high-throughput strategy for the quantification of phenotypic differ...
Image-based cell profiling is a high-throughput strategy for the quantification of phenotypic differ...
Image-based cell profiling is a high-throughput strategy for the quantification of phenotypic differ...
<p>High content screening for drug discovery in cancer research relies increasingly on cell-based mo...
Organotypic, three dimensional (3D) cell culture models of epithelial tumour types such as prostate ...