This dissertation studies mesoscale ocean-atmosphere interaction using the newly developed Scripps Coupled Ocean-Atmosphere Regional (SCOAR) model. The overall goal of this study is to understand the physical processes that lie behind mesoscale ocean-atmosphere interactions and their connection with the basin-scale climate variability.SCOAR allows air-sea feedbacks arising from the oceanic mesoscale features. The model is tested in three scenarios in the eastern Pacific Ocean sector: tropical instability waves (TIWs) of the eastern tropical Pacific; mesoscale eddies and fronts of the California Current System; and gap winds of the Central American Coast. The model reproduces aspects of the observed linear response of the atmosphere to the e...