Herpesviruses rely on a homodimeric protease for viral capsid maturation. A small molecule, DD2, previously shown to disrupt dimerization of Kaposis sarcoma-associated herpesvirus protease (KSHV Pr) by trapping an inactive monomeric conformation and two a
The herpesviruses are an exceptionally interesting pathogen and the cause of lifelong infection for ...
Structurally diverse organophosphonate inhibitors targeting the active site of the enzyme were used ...
The herpesvirus protease is a recently identified enzyme which is essential for viral replication. I...
Herpesviruses rely on a homodimeric protease for viral capsid maturation. A small molecule, DD2, pre...
Human herpesviruses (HHVs) make up one of the most prevalent viral families and are the etiological ...
Kaposi's sarcoma-associated herpesvirus (KSHV), like all herpesviruses, encodes a protease (KSHV Pr)...
Targeting of cryptic binding sites represents an attractive but underexplored approach to modulating...
We identified small-molecule dimer disruptors that inhibit an essential dimeric protease of human Ka...
ABSTRACT: The structure of Kaposi’s sarcoma-associated herpesvirus protease (KSHV Pr), at 2.2 Å reso...
The human herpesviruses (HHVs) make up one of the most prevalent families of human viral pathogens. ...
ABSTRACT: The structure of Kaposi’s sarcoma-associated herpesvirus protease (KSHV Pr), at 2.2 Å reso...
The human herpesviruses (HHVs) make up one of the most prevalent families of human viral pathogens. ...
ABSTRACT: Distinct mechanisms have evolved to regulate the function of proteolytic enzymes. Viral pr...
Viruses are responsible for some of the most deadly human diseases, yet available vaccines and antiv...
Viruses are responsible for some of the most deadly human diseases, yet available vaccines and antiv...
The herpesviruses are an exceptionally interesting pathogen and the cause of lifelong infection for ...
Structurally diverse organophosphonate inhibitors targeting the active site of the enzyme were used ...
The herpesvirus protease is a recently identified enzyme which is essential for viral replication. I...
Herpesviruses rely on a homodimeric protease for viral capsid maturation. A small molecule, DD2, pre...
Human herpesviruses (HHVs) make up one of the most prevalent viral families and are the etiological ...
Kaposi's sarcoma-associated herpesvirus (KSHV), like all herpesviruses, encodes a protease (KSHV Pr)...
Targeting of cryptic binding sites represents an attractive but underexplored approach to modulating...
We identified small-molecule dimer disruptors that inhibit an essential dimeric protease of human Ka...
ABSTRACT: The structure of Kaposi’s sarcoma-associated herpesvirus protease (KSHV Pr), at 2.2 Å reso...
The human herpesviruses (HHVs) make up one of the most prevalent families of human viral pathogens. ...
ABSTRACT: The structure of Kaposi’s sarcoma-associated herpesvirus protease (KSHV Pr), at 2.2 Å reso...
The human herpesviruses (HHVs) make up one of the most prevalent families of human viral pathogens. ...
ABSTRACT: Distinct mechanisms have evolved to regulate the function of proteolytic enzymes. Viral pr...
Viruses are responsible for some of the most deadly human diseases, yet available vaccines and antiv...
Viruses are responsible for some of the most deadly human diseases, yet available vaccines and antiv...
The herpesviruses are an exceptionally interesting pathogen and the cause of lifelong infection for ...
Structurally diverse organophosphonate inhibitors targeting the active site of the enzyme were used ...
The herpesvirus protease is a recently identified enzyme which is essential for viral replication. I...
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