Add to ORKGDiscovering the unintended off-targets that predict adverse drug reactions is daunting by empirical methods alone. Drugs can act on several protein targets, some of which can be unrelated by conventional molecular metrics, and hundreds of proteins have be
Adverse drug reactions (ADRs) are undesired effects of medicines that can harm patients and are a si...
An expanded chemical space is essential for improved identification of small molecules for emerging ...
Computational target prediction methods using chemical descriptors have been applied exhaustively in...
Discovering the unintended “off-targets” that predict adverse drug reactions (ADRs) is daunting by e...
Drug side-effects, or adverse drug reactions, have become a major public health concern and remain o...
Some drugs result in severe side effects. Here we explore two different routes to attack this proble...
Abstract Background Promiscuity in molecular interactions between small-molecules, including drugs, ...
Side effect similarities of drugs have recently been employed to predict new drug targets, and netwo...
In clinical trials, some drugs owe their effectiveness to off-target activity. This and other observ...
To investigate factors contributing to drug side effects, we systematically examine relationships be...
AbstractUnintended effects of drugs can be caused by various mechanisms. Conventional analysis of un...
Whereas drugs are intended to be selective, at least some bind to several physiologic targets, expla...
Most drugs exert their effects via multitarget interactions, as hypothesized by polypharmacology. Wh...
Therapeutic indications and drug side-effects are both measureable human behavioral or physiological...
<div><p>Late-stage or post-market identification of adverse drug reactions (ADRs) is a significant p...
Adverse drug reactions (ADRs) are undesired effects of medicines that can harm patients and are a si...
An expanded chemical space is essential for improved identification of small molecules for emerging ...
Computational target prediction methods using chemical descriptors have been applied exhaustively in...
Discovering the unintended “off-targets” that predict adverse drug reactions (ADRs) is daunting by e...
Drug side-effects, or adverse drug reactions, have become a major public health concern and remain o...
Some drugs result in severe side effects. Here we explore two different routes to attack this proble...
Abstract Background Promiscuity in molecular interactions between small-molecules, including drugs, ...
Side effect similarities of drugs have recently been employed to predict new drug targets, and netwo...
In clinical trials, some drugs owe their effectiveness to off-target activity. This and other observ...
To investigate factors contributing to drug side effects, we systematically examine relationships be...
AbstractUnintended effects of drugs can be caused by various mechanisms. Conventional analysis of un...
Whereas drugs are intended to be selective, at least some bind to several physiologic targets, expla...
Most drugs exert their effects via multitarget interactions, as hypothesized by polypharmacology. Wh...
Therapeutic indications and drug side-effects are both measureable human behavioral or physiological...
<div><p>Late-stage or post-market identification of adverse drug reactions (ADRs) is a significant p...
Adverse drug reactions (ADRs) are undesired effects of medicines that can harm patients and are a si...
An expanded chemical space is essential for improved identification of small molecules for emerging ...
Computational target prediction methods using chemical descriptors have been applied exhaustively in...