Add to ORKGIndividual cells within a tumour can exhibit distinct genetic and molecular features. The impact of such diversification on metastatic potential is unknown. Here we identify clonal human breast cancer subpopulations that display different levels of morpho
Breast cancer is the most prevalent type of cancer in the united states with a high mortality rate d...
A major component of cancer’s complexity lies in its heterogeneity. Because cancer heterogeneity can...
The heterogeneity of breast cancer plays a major role in drug response and resistance and has been e...
Metastatic disease is the main cause of cancer-related mortality due to almost universal therapeutic...
Unlike the great advances that have been made in reducing breast cancer mortality through the multid...
Breast cancer is a remarkably complex and diverse disease. Subtyping based on morphology, genomics, ...
Breast cancer (BC) represents a major clinical hurdle, with metastatic outcome accounting for poor p...
Intratumoral heterogeneity is a driver of breast cancer progression, but the nature of the clonal in...
Heterogeneity within a tumour increases its ability to adapt to constantly changing constraints, but...
Endocrine therapy is the mainstay of treatment for luminal breast cancer. Despite the widespread suc...
Cancers may be composed of multiple populations of submodal clones sharing the same initiating genet...
Metastatic disease is themain cause of cancer-relatedmortality due to almost universal therapeutic r...
BackgroundCancer metastasis is a complex process involving the spread of malignant cells from a prim...
SummaryPathways that govern stem cell (SC) function are often subverted in cancer. Here, we report t...
AbstractThe heterogeneity of breast cancer plays a major role in drug response and resistance and ha...
Breast cancer is the most prevalent type of cancer in the united states with a high mortality rate d...
A major component of cancer’s complexity lies in its heterogeneity. Because cancer heterogeneity can...
The heterogeneity of breast cancer plays a major role in drug response and resistance and has been e...
Metastatic disease is the main cause of cancer-related mortality due to almost universal therapeutic...
Unlike the great advances that have been made in reducing breast cancer mortality through the multid...
Breast cancer is a remarkably complex and diverse disease. Subtyping based on morphology, genomics, ...
Breast cancer (BC) represents a major clinical hurdle, with metastatic outcome accounting for poor p...
Intratumoral heterogeneity is a driver of breast cancer progression, but the nature of the clonal in...
Heterogeneity within a tumour increases its ability to adapt to constantly changing constraints, but...
Endocrine therapy is the mainstay of treatment for luminal breast cancer. Despite the widespread suc...
Cancers may be composed of multiple populations of submodal clones sharing the same initiating genet...
Metastatic disease is themain cause of cancer-relatedmortality due to almost universal therapeutic r...
BackgroundCancer metastasis is a complex process involving the spread of malignant cells from a prim...
SummaryPathways that govern stem cell (SC) function are often subverted in cancer. Here, we report t...
AbstractThe heterogeneity of breast cancer plays a major role in drug response and resistance and ha...
Breast cancer is the most prevalent type of cancer in the united states with a high mortality rate d...
A major component of cancer’s complexity lies in its heterogeneity. Because cancer heterogeneity can...
The heterogeneity of breast cancer plays a major role in drug response and resistance and has been e...