Adults with Down syndrome (DS) develop Alzheimer's disease (AD) neuropathology by 40 years of age. Synaptophysin (SYN) consistently declines with age and is further reduced with sporadic AD. Thus, we hypothesized that SYN would be reduced in DS with AD. The gene for synaptojanin-1 (SYNJ1), involved in synaptic vesicle recycling, is on chromosome 21. We measured SYN and SYNJ1 in an autopsy series of 39 cases with DS and 28 without DS, along with 7 sporadic AD cases. SYN was significantly lower in DSAD compared with DS alone and similar to sporadic AD. Reduced SYN is associated with AD neuropathology and with Aβ levels in DS, as is seen in sporadic AD. SYNJ1 was significantly higher in DS and correlated with several measures of Aβ. SYNJ1 was ...
Down syndrome (DS) is a genetically-based disorder which results in multiple conditions for sufferer...
Down syndrome (DS) is one of the most common causes of intellectual disability, owing to trisomy of ...
The phosphoinositide phosphatase synaptojanin 1 (SYNJ1) is a key regulator of synaptic function. We ...
Adults with Down syndrome (DS) develop Alzheimer's disease (AD) neuropathology by 40 years of age. S...
The phosphoinositide phosphatase synaptojanin 1 (SYNJ1) is a key regulator of synaptic function. We ...
Enlarged early endosomes have been observed in neurons and fibroblasts in Down syndrome (DS). These ...
Chromosome 21, triplicated in Down Syndrome, contains several genes that are thought to play a criti...
Down syndrome (DS) patients demonstrate the neuropathology of Alzheimer's disease (AD) characterized...
Down syndrome (DS) patients demonstrate the neuropathology of Alzheimer\u27s disease (AD) characteri...
Down syndrome (DS) is the most common genetic cause of Alzheimer's disease (AD) due to trisomy for a...
People with Down syndrome (DS) virtually all develop intellectual disability (ID) of varying degree ...
Enlarged early endosomes have been observed in neurons and fibroblasts in Down syndrome (DS). These ...
Alzheimer’s disease (AD) is the most prevalent type of dementia. Down syndrome (DS) is the leading g...
Down syndrome (DS) patients unanimously develop pathologies of Alzheimer’s disease (AD) in their 30s...
Overexpression of the amyloid precursor protein (APP) gene on chromosome 21 in Down syndrome (DS) ha...
Down syndrome (DS) is a genetically-based disorder which results in multiple conditions for sufferer...
Down syndrome (DS) is one of the most common causes of intellectual disability, owing to trisomy of ...
The phosphoinositide phosphatase synaptojanin 1 (SYNJ1) is a key regulator of synaptic function. We ...
Adults with Down syndrome (DS) develop Alzheimer's disease (AD) neuropathology by 40 years of age. S...
The phosphoinositide phosphatase synaptojanin 1 (SYNJ1) is a key regulator of synaptic function. We ...
Enlarged early endosomes have been observed in neurons and fibroblasts in Down syndrome (DS). These ...
Chromosome 21, triplicated in Down Syndrome, contains several genes that are thought to play a criti...
Down syndrome (DS) patients demonstrate the neuropathology of Alzheimer's disease (AD) characterized...
Down syndrome (DS) patients demonstrate the neuropathology of Alzheimer\u27s disease (AD) characteri...
Down syndrome (DS) is the most common genetic cause of Alzheimer's disease (AD) due to trisomy for a...
People with Down syndrome (DS) virtually all develop intellectual disability (ID) of varying degree ...
Enlarged early endosomes have been observed in neurons and fibroblasts in Down syndrome (DS). These ...
Alzheimer’s disease (AD) is the most prevalent type of dementia. Down syndrome (DS) is the leading g...
Down syndrome (DS) patients unanimously develop pathologies of Alzheimer’s disease (AD) in their 30s...
Overexpression of the amyloid precursor protein (APP) gene on chromosome 21 in Down syndrome (DS) ha...
Down syndrome (DS) is a genetically-based disorder which results in multiple conditions for sufferer...
Down syndrome (DS) is one of the most common causes of intellectual disability, owing to trisomy of ...
The phosphoinositide phosphatase synaptojanin 1 (SYNJ1) is a key regulator of synaptic function. We ...