Rationale: Pre-existing cardiomyocytes and resident cardiac stem cells are limited in their capacity for substantial regeneration in postnatal endogenous mammalian myocardial repair. Evidence for adult cardiomyocyte proliferation remains inconclusive, relying on proliferation markers that also present in hypertrophy or DNA repair. Unambiguous identification of myocyte cell cycle activity to demarcate de novo cardiomyogenesis within the injured myocardium has not been achieved using traditional markers of cellular proliferation. A powerful tool, Fluorescence Ubiquitination-based Cell Cycle Indicators (FUCCI) reporter system utilized to examine dynamic oscillations between G1 and S/G2/M phases of the cell cycle has yet to be exploited in a ca...
Cardiac regeneration involves the generation of new cardiomyocytes from cycling cardiomyocytes. Unde...
Abstract—Cardiomyocytes withdraw from the cell cycle in the early neonatal period, rendering the adu...
International audienceOver the last two decades, considerable effort has been made to better underst...
Cardiomyocytes exhibit robust proliferative activity during development. After birth, cardiomyocyte ...
Cardiac diseases such as myocardial infarction (MI) can lead to adverse remodeling and impaired cont...
Adult mammalian cardiomyocytes (CMs) exhibit limited proliferative capacity, as cell cycle activity ...
Cardiac repair following myocardial injury is restricted due to the limited proliferative potential ...
RationaleDiscerning cardiac myocyte cell cycle behavior is challenging owing to commingled cell type...
AIMS: Adult mammalian cardiomyocytes are traditionally viewed as being permanently withdrawn from th...
The cellular mechanisms driving cardiac tissue formation remain poorly understood, largely due to th...
The human heart is known to have limited regenerative capacity, with minimal proliferation of pre-ex...
Many forms of cardiac disease are characterized by cardiomyocyte death due to necrosis, apoptosis an...
The human heart is known to have limited regenerative capacity, with minimal proliferation of pre-ex...
International audienceCardiac diseases, characterized by cardiomyocyte loss, lead to dramatic impair...
Neonatal and adult cardiomyocytes were isolated from rat hearts. Some of the adult myocytes were cul...
Cardiac regeneration involves the generation of new cardiomyocytes from cycling cardiomyocytes. Unde...
Abstract—Cardiomyocytes withdraw from the cell cycle in the early neonatal period, rendering the adu...
International audienceOver the last two decades, considerable effort has been made to better underst...
Cardiomyocytes exhibit robust proliferative activity during development. After birth, cardiomyocyte ...
Cardiac diseases such as myocardial infarction (MI) can lead to adverse remodeling and impaired cont...
Adult mammalian cardiomyocytes (CMs) exhibit limited proliferative capacity, as cell cycle activity ...
Cardiac repair following myocardial injury is restricted due to the limited proliferative potential ...
RationaleDiscerning cardiac myocyte cell cycle behavior is challenging owing to commingled cell type...
AIMS: Adult mammalian cardiomyocytes are traditionally viewed as being permanently withdrawn from th...
The cellular mechanisms driving cardiac tissue formation remain poorly understood, largely due to th...
The human heart is known to have limited regenerative capacity, with minimal proliferation of pre-ex...
Many forms of cardiac disease are characterized by cardiomyocyte death due to necrosis, apoptosis an...
The human heart is known to have limited regenerative capacity, with minimal proliferation of pre-ex...
International audienceCardiac diseases, characterized by cardiomyocyte loss, lead to dramatic impair...
Neonatal and adult cardiomyocytes were isolated from rat hearts. Some of the adult myocytes were cul...
Cardiac regeneration involves the generation of new cardiomyocytes from cycling cardiomyocytes. Unde...
Abstract—Cardiomyocytes withdraw from the cell cycle in the early neonatal period, rendering the adu...
International audienceOver the last two decades, considerable effort has been made to better underst...