Despite the need to better understand the changing dynamics between the ongoing political regionalization processes and the re-scaling of nation-states, at least in Europe, updated and timely research that responds to these challenges fueled by data-driven societies and the algorithmic revolution invigorated by an uneven establishment of borders remains scant and ambiguous. Nations, regardless of the spatial boundary by which we define them, matter as much as political borders and account for algorithmic disruption. Hence, this paper explores these new cartographies from the regional studies perspective by presenting the city-region as a pivotal term amidst a wide range of challenges for cities, regions, and nation-states. The Basque Countr...