Endothelial dysfunction is induced by inflammatory mediators including multiple G protein-coupled receptor (GPCR) agonists. However, the GPCR signaling pathways that promote endothelial dysfunction are incompletely understood. We previously showed that thrombin promotes endothelial barrier disruption through autophosphorylation and activation of p38 mitogen-activated protein kinase (MAPK) via a non-canonical transforming growth factor-β-activated protein kinase-1-binding protein-1 (TAB1) and TAB2-dependent pathway rather than the canonical three-tiered kinase cascade. Here, we sought to determine whether other GPCR agonists stimulate p38 MAPK activation via this non-canonical pathway in human endothelial cells derived from different vascula...
The endothelial regulation of platelet activity is incompletely understood. Here we describe novel a...
G protein-coupled receptors (GPCR) convey messages via three main mechanisms: the classical pathway,...
Ubiquitination is essential for protein degradation and signaling and pivotal to many physiological ...
Endothelial dysfunction is a hallmark of inflammation and is mediated by inflammatory factors that s...
Protease-activated receptor 1 (PAR1) is a G protein-coupled receptor (GPCR) for thrombin and promote...
International audienceBy gating the traffic of molecules and cells across the vessel wall, endotheli...
G-coupled protein receptors (GPCRs) comprise the largest class of druggable targets. Signaling by GP...
Vascular inflammation causes endothelial barrier disruption and tissue edema. Several inflammatory m...
Summary: Ubiquitination is essential for protein degradation and signaling and pivotal to many physi...
Tumour necrosis factor (TNF) is a pro-inflammatory cytokine, whose primary targets include vascular ...
L911–L918, 2004; doi:10.1152/ajplung.00372.2003.—We have pre-viously shown that thrombin induces end...
Aims: G protein-coupled receptor (GPCR) transactivation of kinase receptors greatly expands the acti...
p38 MAP kinase in human platelets is activated by platelet agonists including thrombin, thromboxane ...
AbstractUsing a signal sequence trap for selection of differentially expressed secretory and membran...
Endothelial apoptosis plays an important role in atherosclerosis, and a direct proapoptotic effect o...
The endothelial regulation of platelet activity is incompletely understood. Here we describe novel a...
G protein-coupled receptors (GPCR) convey messages via three main mechanisms: the classical pathway,...
Ubiquitination is essential for protein degradation and signaling and pivotal to many physiological ...
Endothelial dysfunction is a hallmark of inflammation and is mediated by inflammatory factors that s...
Protease-activated receptor 1 (PAR1) is a G protein-coupled receptor (GPCR) for thrombin and promote...
International audienceBy gating the traffic of molecules and cells across the vessel wall, endotheli...
G-coupled protein receptors (GPCRs) comprise the largest class of druggable targets. Signaling by GP...
Vascular inflammation causes endothelial barrier disruption and tissue edema. Several inflammatory m...
Summary: Ubiquitination is essential for protein degradation and signaling and pivotal to many physi...
Tumour necrosis factor (TNF) is a pro-inflammatory cytokine, whose primary targets include vascular ...
L911–L918, 2004; doi:10.1152/ajplung.00372.2003.—We have pre-viously shown that thrombin induces end...
Aims: G protein-coupled receptor (GPCR) transactivation of kinase receptors greatly expands the acti...
p38 MAP kinase in human platelets is activated by platelet agonists including thrombin, thromboxane ...
AbstractUsing a signal sequence trap for selection of differentially expressed secretory and membran...
Endothelial apoptosis plays an important role in atherosclerosis, and a direct proapoptotic effect o...
The endothelial regulation of platelet activity is incompletely understood. Here we describe novel a...
G protein-coupled receptors (GPCR) convey messages via three main mechanisms: the classical pathway,...
Ubiquitination is essential for protein degradation and signaling and pivotal to many physiological ...