Histological analysis of extraction sockets grafted with Platelet Rich Fibrin in comparison to Freeze Dried Bone Allograft

AbstractObjective: The present study is a randomized controlled clinical trial that aims to evaluate histological bone healing of platelet rich fibrins (PRF) in comparison to natural healing, and freeze-dried bone allografts (FDBA).Methods: Forty patients were recruited, randomized and treated in one of the following four groups: group A blood clot (control), group B PRF, group C PRF mixed with 1:1 ratio of FDBA and group D FDBA. Single rooted teeth were extracted and the sockets were treated in accordance to the protocol for each group. Extraction sockets were covered using Collaplug. After 12 weeks, bone core samples were removed prior to implant placement. Clinical dimensional changes, Micro-CT and histological analysis were completed.Results: Histological studies of H&E slides demonstrated the percent area of vital bone was 38.59% in group A, 53.71% in group B, 41.31% in group C and 29.06% in group D. There was a statistical significance between vital bone percentage between the PRF group and FDBA group (student t-test).Conclusion: This study provides the first histological evidence to our knowledge that PRF in extraction socket can significantly improve vital bone quality after 12 weeks of healing