G protein-coupled receptors (GPCRs) comprise the largest family of transmembrane signaling receptors known and account for roughly half of all pharmaceutical targets. Receptor regulation is known to influence cellular signaling strength and specificity, but the mechanisms conferring cellular-level regulation are largely unclear. An important process impacting cellular sensitivity is the post-endocytic sorting of receptors between a downregulating lysosomal fate and a resensitizing recycling pathway to the cell surface. GPCR recycling, in particular, is itself a regulated process that requires recognition of cytoplasmic receptor motifs. The first motif recognized as a recycling sequence is a protein interaction ligand found at the C-term...
G protein-coupled receptors (GPCRs) are important cell signaling mediators, involved in essential ph...
Recycling of the mu opioid receptor to the plasma membrane after endocytosis promotes rapid resensit...
Using the yeast two-hybrid system, we identified ezrin as a protein interacting with the C-tail of t...
A defining feature of the eukaryotic cell is the abundance and diversity of membranous organelles. T...
<p>Cellular responses to environmental signals are mediated by a host of signal transduction protein...
<p>Postendocytic sorting of G protein-coupled receptors (GPCRs) is driven by their interactions betw...
Postendocytic sorting of G protein-coupled receptors (GPCRs) is driven by their interactions between...
The functional consequences of signaling receptor endocytosis are determined by the endosomal sortin...
The postendocytic recycling of signaling receptors is subject to multiple requirements. Why this is ...
SummaryThe functional consequences of signaling receptor endocytosis are determined by the endosomal...
This thesis addresses the endosomal sorting of the beta-2 adrenergic receptor (B2AR), a "typical" (f...
The heptahelical G protein–coupled receptors (GPCRs) belong to the largest family of cell surface si...
AbstractG protein-coupled receptors (GPCRs) constitute a superfamily of cell-surface receptors which...
The ability of G protein-coupled receptors (GPCRs) to initiate complex cascades of cellular signalin...
The heptahelical G protein-coupled receptors (GPCRs) must reach their correct subcellular location t...
G protein-coupled receptors (GPCRs) are important cell signaling mediators, involved in essential ph...
Recycling of the mu opioid receptor to the plasma membrane after endocytosis promotes rapid resensit...
Using the yeast two-hybrid system, we identified ezrin as a protein interacting with the C-tail of t...
A defining feature of the eukaryotic cell is the abundance and diversity of membranous organelles. T...
<p>Cellular responses to environmental signals are mediated by a host of signal transduction protein...
<p>Postendocytic sorting of G protein-coupled receptors (GPCRs) is driven by their interactions betw...
Postendocytic sorting of G protein-coupled receptors (GPCRs) is driven by their interactions between...
The functional consequences of signaling receptor endocytosis are determined by the endosomal sortin...
The postendocytic recycling of signaling receptors is subject to multiple requirements. Why this is ...
SummaryThe functional consequences of signaling receptor endocytosis are determined by the endosomal...
This thesis addresses the endosomal sorting of the beta-2 adrenergic receptor (B2AR), a "typical" (f...
The heptahelical G protein–coupled receptors (GPCRs) belong to the largest family of cell surface si...
AbstractG protein-coupled receptors (GPCRs) constitute a superfamily of cell-surface receptors which...
The ability of G protein-coupled receptors (GPCRs) to initiate complex cascades of cellular signalin...
The heptahelical G protein-coupled receptors (GPCRs) must reach their correct subcellular location t...
G protein-coupled receptors (GPCRs) are important cell signaling mediators, involved in essential ph...
Recycling of the mu opioid receptor to the plasma membrane after endocytosis promotes rapid resensit...
Using the yeast two-hybrid system, we identified ezrin as a protein interacting with the C-tail of t...