The human immunodeficiency virus (HIV) protein Rev plays a central role in the viral lifecycle by post-transcriptionally regulating the expression of structural and envelope proteins and by providing genomic RNA for new virions. Rev accomplishes these tasks by interfacing with the host nuclear transport machinery to facilitate the nuclear export of unspliced and partially spliced viral RNAs. A cis-acting element within these RNAs, the Rev Response Element (RRE), directs the assembly of a Rev homoligomer that recruits the nuclear export adaptors Crm1 and Ran. In this dissertation, I share my efforts to understand this critical host-virus interaction. By providing the first structure of the entire complex with supporting biochemistry, this wo...
International audienceThe HIV-1 Rev protein mediates export of unspliced and singly spliced viral tr...
Human immunodeficiency virus type I (HIV-1) is a retrovirus that causes acquired immunodeficiency sy...
Background: human cell types respond differently to infection by human immunodeficiency virus (HIV)....
The human immunodeficiency virus (HIV) protein Rev plays a central role in the viral lifecycle by po...
The HIV Rev protein routes viral RNAs containing the Rev Response Element (RRE) through the Crm1 nuc...
HIV-1 Rev is a protein responsible for transporting partially spliced and fully unspliced HIV-1 RNA ...
Replication of HIV requires the nuclear export of unspliced viral RNAs for the translation of struct...
HIV replication requires nuclear export of unspliced and singly spliced viral transcripts. Although ...
HIV replication requires nuclear export of unspliced viral RNAs to translate structural proteins and...
To export intron-containing viral mRNAs that encode the structural components of new viral particles...
HIV-1 Rev is an ~13 kD accessory protein expressed during the early stage of virus replication. Afte...
HIV-1 Rev protein mediates the nuclear export of viral RNA genomes. To do so, Rev oli...
It has been known for some time that the HIV Rev protein binds and oligomerizes on a well-defined mu...
Retroviruses have evolved sophisticated mechanisms to ensure timely export of incompletely spliced v...
The human immunodeficiency virus type-1 (HIV-1) Rev protein regulates the nuclear export of intron-c...
International audienceThe HIV-1 Rev protein mediates export of unspliced and singly spliced viral tr...
Human immunodeficiency virus type I (HIV-1) is a retrovirus that causes acquired immunodeficiency sy...
Background: human cell types respond differently to infection by human immunodeficiency virus (HIV)....
The human immunodeficiency virus (HIV) protein Rev plays a central role in the viral lifecycle by po...
The HIV Rev protein routes viral RNAs containing the Rev Response Element (RRE) through the Crm1 nuc...
HIV-1 Rev is a protein responsible for transporting partially spliced and fully unspliced HIV-1 RNA ...
Replication of HIV requires the nuclear export of unspliced viral RNAs for the translation of struct...
HIV replication requires nuclear export of unspliced and singly spliced viral transcripts. Although ...
HIV replication requires nuclear export of unspliced viral RNAs to translate structural proteins and...
To export intron-containing viral mRNAs that encode the structural components of new viral particles...
HIV-1 Rev is an ~13 kD accessory protein expressed during the early stage of virus replication. Afte...
HIV-1 Rev protein mediates the nuclear export of viral RNA genomes. To do so, Rev oli...
It has been known for some time that the HIV Rev protein binds and oligomerizes on a well-defined mu...
Retroviruses have evolved sophisticated mechanisms to ensure timely export of incompletely spliced v...
The human immunodeficiency virus type-1 (HIV-1) Rev protein regulates the nuclear export of intron-c...
International audienceThe HIV-1 Rev protein mediates export of unspliced and singly spliced viral tr...
Human immunodeficiency virus type I (HIV-1) is a retrovirus that causes acquired immunodeficiency sy...
Background: human cell types respond differently to infection by human immunodeficiency virus (HIV)....