Incubation of craving is the phenomenon in which craving intensifies over the course of abstinence. Although understanding craving may be key in understanding why relapse occurs, not much is known about craving, especially the underlying mechanisms that occur in the brain. Clinical and preclinical models have recently implicated the ventromedial prefrontal cortex as one of the key regions in this phenomenon. In order to further characterize this region’s role in incubation, a variety of behavioral, pharmacological, and molecular techniques are used to examine how withdrawal from long access cocaine self-administration directly affects the glutamatergic system. The series of experiments detailed in this dissertation aim to: (1) characterize ...
Glutamate signaling in prefrontal cortex and ventral tegmental area plays an important role in the m...
Glutamate signaling in prefrontal cortex and ventral tegmental area plays an important role in the m...
Cue-elicited drug-craving correlates with hyperactivity within prefrontal cortex (PFC), which is the...
Craving elicited by drug-associated cues intensifies across protracted drug abstinence - a phenomeno...
IntroductionIncubation of drug-craving refers to a time-dependent increase in drug cue-elicited crav...
High rates of relapse after prolonged abstinence are often triggered by exposure to drug-associated ...
High rates of relapse after prolonged abstinence are often triggered by exposure to drug-associated ...
A diagnostic criterion for drug addiction, persistent drug-craving continues to be the most treatmen...
A diagnostic criterion for drug addiction, persistent drug-craving continues to be the most treatmen...
Prime diagnostic criteria for drug addiction include uncontrollable urges to obtain drugs and reduce...
Background: We and others reported time-dependent increases in cue-induced cocaine seeking after wit...
Prime diagnostic criteria for drug addiction include uncontrollable urges to obtain drugs and reduce...
Craving is a core symptom of cocaine use disorder and a major factor for relapse risk. To date, ther...
Cue-elicited drug-craving is a cardinal feature of addiction that intensifies (incubates) during pro...
Cue-elicited drug-craving is a cardinal feature of addiction that intensifies (incubates) during pro...
Glutamate signaling in prefrontal cortex and ventral tegmental area plays an important role in the m...
Glutamate signaling in prefrontal cortex and ventral tegmental area plays an important role in the m...
Cue-elicited drug-craving correlates with hyperactivity within prefrontal cortex (PFC), which is the...
Craving elicited by drug-associated cues intensifies across protracted drug abstinence - a phenomeno...
IntroductionIncubation of drug-craving refers to a time-dependent increase in drug cue-elicited crav...
High rates of relapse after prolonged abstinence are often triggered by exposure to drug-associated ...
High rates of relapse after prolonged abstinence are often triggered by exposure to drug-associated ...
A diagnostic criterion for drug addiction, persistent drug-craving continues to be the most treatmen...
A diagnostic criterion for drug addiction, persistent drug-craving continues to be the most treatmen...
Prime diagnostic criteria for drug addiction include uncontrollable urges to obtain drugs and reduce...
Background: We and others reported time-dependent increases in cue-induced cocaine seeking after wit...
Prime diagnostic criteria for drug addiction include uncontrollable urges to obtain drugs and reduce...
Craving is a core symptom of cocaine use disorder and a major factor for relapse risk. To date, ther...
Cue-elicited drug-craving is a cardinal feature of addiction that intensifies (incubates) during pro...
Cue-elicited drug-craving is a cardinal feature of addiction that intensifies (incubates) during pro...
Glutamate signaling in prefrontal cortex and ventral tegmental area plays an important role in the m...
Glutamate signaling in prefrontal cortex and ventral tegmental area plays an important role in the m...
Cue-elicited drug-craving correlates with hyperactivity within prefrontal cortex (PFC), which is the...