Add to ORKGCerebral deposition of amyloid beta peptide (Abeta) is an early and critical feature of Alzheimer's disease. Abeta generation depends on proteolytic cleavage of the amyloid precursor protein (APP) by two unknown proteases: beta-secretase and gamma-secretase. These proteases are prime therapeutic targets. A transmembrane aspartic protease with all the known characteristics of beta-secretase was cloned and characterized. Overexpression of this protease, termed BACE (for beta-site APP-cleaving enzyme) increased the amount of beta-secretase cleavage products, and these were cleaved exactly and only at known beta-secretase positions. Antisense inhibition of endogenous BACE messenger RNA decreased the amount of beta-secretase cleavage products, a...
C1 - Journal Articles RefereedAccumulation of Abeta peptide in the brain results in the formation of...
Cleavage of the amyloid precursor protein by enzymes commonly referred to as β- and γ-secretase cons...
BACE1 (beta-site amyloid precursor protein cleaving enzyme 1) was initially cloned and characterized...
Cerebral deposition of amyloid beta peptide (Abeta) is an early and critical feature of Alzheimer's ...
Cerebral deposition of amyloid b peptide (Ab) is an early and critical feature of AlzheimerÕs diseas...
Cerebral deposition of amyloid β peptide (Aβ) is an early and critical feature of Alzheimer's diseas...
beta-Site amyloid precursor protein cleavage enzyme (BACE)-1 and BACE-2 are members of a novel famil...
AbstractProteolytic cleavage of the amyloid protein from the amyloid protein precursor (APP) by APP ...
Two enzymatic activities are required to generate the pathogenic beta-amyloid (Abeta) peptide that a...
β-Secretase (BACE1 or β-site APP cleaving enzyme) is an acid protease that releases the neurotoxic 4...
Accumulation of the amyloid-β (Aβ) peptide in the central nervous system (CNS) is considered by many...
The beta-amyloid precursor protein (betaAPP) is proteolytically processed by two secretase activitie...
The amyloid precursor family of proteins are of considerable interest, both because of their role in...
Alzheimer’s disease (AD) is a growing global health concern with a massive impact on affected ...
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by accumulation of amyloid pl...
C1 - Journal Articles RefereedAccumulation of Abeta peptide in the brain results in the formation of...
Cleavage of the amyloid precursor protein by enzymes commonly referred to as β- and γ-secretase cons...
BACE1 (beta-site amyloid precursor protein cleaving enzyme 1) was initially cloned and characterized...
Cerebral deposition of amyloid beta peptide (Abeta) is an early and critical feature of Alzheimer's ...
Cerebral deposition of amyloid b peptide (Ab) is an early and critical feature of AlzheimerÕs diseas...
Cerebral deposition of amyloid β peptide (Aβ) is an early and critical feature of Alzheimer's diseas...
beta-Site amyloid precursor protein cleavage enzyme (BACE)-1 and BACE-2 are members of a novel famil...
AbstractProteolytic cleavage of the amyloid protein from the amyloid protein precursor (APP) by APP ...
Two enzymatic activities are required to generate the pathogenic beta-amyloid (Abeta) peptide that a...
β-Secretase (BACE1 or β-site APP cleaving enzyme) is an acid protease that releases the neurotoxic 4...
Accumulation of the amyloid-β (Aβ) peptide in the central nervous system (CNS) is considered by many...
The beta-amyloid precursor protein (betaAPP) is proteolytically processed by two secretase activitie...
The amyloid precursor family of proteins are of considerable interest, both because of their role in...
Alzheimer’s disease (AD) is a growing global health concern with a massive impact on affected ...
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by accumulation of amyloid pl...
C1 - Journal Articles RefereedAccumulation of Abeta peptide in the brain results in the formation of...
Cleavage of the amyloid precursor protein by enzymes commonly referred to as β- and γ-secretase cons...
BACE1 (beta-site amyloid precursor protein cleaving enzyme 1) was initially cloned and characterized...