Add to ORKGIn vitro selection and structure-based searches have emerged as useful techniques for the discoveries of structurally complex RNAs with high affinity and specificity toward metabolites. Here, we focus on the design of a human genomic library that serves as the DNA template for in vitro selection of RNA aptamers. In addition, the structural solutions obtained from the in vitro selection can be used for structure-based searches for discovery of analogous aptamers in various genomic databases
Aptamers are an emerging class of molecules that are valued for their ability to bind with high affi...
Riboswitches and RNA interference are important emerging mechanisms found in many organisms to contr...
Laboratory-evolved RNAs bind a wide variety of targets and serve highly diverse functions, including...
In vitro selection and structure-based searches have emerged as useful techniques for the discoverie...
Biochemical properties of ribonucleic acids enable their instrumentality in physiological functions....
Laboratory-evolved RNAs bind a wide variety of targets and serve highly diverse functions, including...
Aptamers are small, functional nucleic acids that bind a variety of targets, often with high specifi...
Aptamers are discovered from random oligonucleotide libraries by an in vitro selection process, u...
In vitro selection of RNA aptamers that bind to a specific ligand usually begins with a random pool ...
In the past five decades, several landmark discoveries have demonstrated that nucleic acids are a mu...
Background Catalytic RNA molecules are called ribozymes. The aptamers are DNA or RNA molecules that ...
Nucleic acid aptamers capable of selectively recognizing their target molecules have nowadays been e...
Next to its function as information carrier (mRNA), RNA plays an important role in different regulat...
The more we learn to read the instructions encoding the functions of all life, the more we realize h...
AbstractAptamers are RNA or DNA oligonucleotides identified within a randomly synthesized library, t...
Aptamers are an emerging class of molecules that are valued for their ability to bind with high affi...
Riboswitches and RNA interference are important emerging mechanisms found in many organisms to contr...
Laboratory-evolved RNAs bind a wide variety of targets and serve highly diverse functions, including...
In vitro selection and structure-based searches have emerged as useful techniques for the discoverie...
Biochemical properties of ribonucleic acids enable their instrumentality in physiological functions....
Laboratory-evolved RNAs bind a wide variety of targets and serve highly diverse functions, including...
Aptamers are small, functional nucleic acids that bind a variety of targets, often with high specifi...
Aptamers are discovered from random oligonucleotide libraries by an in vitro selection process, u...
In vitro selection of RNA aptamers that bind to a specific ligand usually begins with a random pool ...
In the past five decades, several landmark discoveries have demonstrated that nucleic acids are a mu...
Background Catalytic RNA molecules are called ribozymes. The aptamers are DNA or RNA molecules that ...
Nucleic acid aptamers capable of selectively recognizing their target molecules have nowadays been e...
Next to its function as information carrier (mRNA), RNA plays an important role in different regulat...
The more we learn to read the instructions encoding the functions of all life, the more we realize h...
AbstractAptamers are RNA or DNA oligonucleotides identified within a randomly synthesized library, t...
Aptamers are an emerging class of molecules that are valued for their ability to bind with high affi...
Riboswitches and RNA interference are important emerging mechanisms found in many organisms to contr...
Laboratory-evolved RNAs bind a wide variety of targets and serve highly diverse functions, including...