Add to ORKGRecent evidence suggests that autophagy facilitates the unconventional secretion of the pro-inflammatory cytokine interleukin 1β (IL-1β). Here, we reconstituted an autophagy-regulated secretion of mature IL-1β (m-IL-1β) in non-macrophage cells. We found that cytoplasmic IL-1β associates with the autophagosome and m-IL-1β enters into the lumen of a vesicle intermediate but not into the cytoplasmic interior formed by engulfment of the autophagic membrane. In advance of secretion, m-IL-1β appears to be translocated across a membrane in an event that may require m-IL-1β to be unfolded or remain conformationally flexible and is dependent on two KFERQ-like motifs essential for the association of IL-1β with HSP90. A vesicle, possibly a precursor o...
SummaryToll-like receptor-9 (TLR9) is largely responsible for discriminating self from pathogenic DN...
Commonly referred as autophagy, macroautophagy is one of the major degradative pathways in eukaryoti...
Inflammasomes are intracellular protein complexes of pattern recognition receptors and caspase-1, wi...
Interleukin-1β (IL-1β), a major pro-inflammatory cytokine, is a leaderless cytosolic protein whose s...
One of the most poorly understood processes in cell biology is the peculiar ability of specific lead...
<p>Interleukin-1β (IL-1β), a major pro-inflammatory cytokine, is a leaderless cytosolic protein whos...
Autophagy is a key regulator of cellular homeostasis that can be activated by pathogen-associated mo...
<p>Interleukin-1β (IL-1β), a major pro-inflammatory cytokine, is a leaderless cytosolic protein whos...
© 2017 Elsevier Ltd Autophagy is a ubiquitous cellular mechanism for the targeted lysosomal degradat...
Summary: IL-1β requires processing by caspase-1 to generate the active, pro-inflammatory cytokine. A...
Autophagy controls the quality and quantity of the eukar-yotic cytoplasm while performing two evolut...
Proteins without signal peptides can still be released into extracellular space via ER/Golgi-indepen...
Interleukin-1β (IL-1β), a major proinflammatory cytokine, is a leaderless cytosolic protein whose se...
In its classical form, autophagy is a pathway by which cytoplasmic constituents, including intracell...
Toll-like receptor-9 (TLR9) is largely responsible for discriminating self from pathogenic DNA. Howe...
SummaryToll-like receptor-9 (TLR9) is largely responsible for discriminating self from pathogenic DN...
Commonly referred as autophagy, macroautophagy is one of the major degradative pathways in eukaryoti...
Inflammasomes are intracellular protein complexes of pattern recognition receptors and caspase-1, wi...
Interleukin-1β (IL-1β), a major pro-inflammatory cytokine, is a leaderless cytosolic protein whose s...
One of the most poorly understood processes in cell biology is the peculiar ability of specific lead...
<p>Interleukin-1β (IL-1β), a major pro-inflammatory cytokine, is a leaderless cytosolic protein whos...
Autophagy is a key regulator of cellular homeostasis that can be activated by pathogen-associated mo...
<p>Interleukin-1β (IL-1β), a major pro-inflammatory cytokine, is a leaderless cytosolic protein whos...
© 2017 Elsevier Ltd Autophagy is a ubiquitous cellular mechanism for the targeted lysosomal degradat...
Summary: IL-1β requires processing by caspase-1 to generate the active, pro-inflammatory cytokine. A...
Autophagy controls the quality and quantity of the eukar-yotic cytoplasm while performing two evolut...
Proteins without signal peptides can still be released into extracellular space via ER/Golgi-indepen...
Interleukin-1β (IL-1β), a major proinflammatory cytokine, is a leaderless cytosolic protein whose se...
In its classical form, autophagy is a pathway by which cytoplasmic constituents, including intracell...
Toll-like receptor-9 (TLR9) is largely responsible for discriminating self from pathogenic DNA. Howe...
SummaryToll-like receptor-9 (TLR9) is largely responsible for discriminating self from pathogenic DN...
Commonly referred as autophagy, macroautophagy is one of the major degradative pathways in eukaryoti...
Inflammasomes are intracellular protein complexes of pattern recognition receptors and caspase-1, wi...