Transforming growth factor-beta 1 (TGF-beta 1) has been implicated in the positive regulation of angiogenesis in vivo, whereas it inhibits the proliferation of endothelial cells in vitro. To reconcile these apparently contradictory effects, we have investigated the effect of TGF-beta 1 on bovine aortic endothelial cells that exhibit spontaneous angiogenesis in vitro. We show that concentrations of TGF-beta 1 which stimulate proliferation of cells that form endothelial cords and/or tubes inhibit proliferation of the same cells grown at subconfluent densities. An increase in cell number of 35% over control cultures was achieved with 0.5 ng TGF-beta 1/ml. The proliferative effect was blocked by antibodies against TGF-beta. Immunological detect...
Angiogenesis, the formation of new blood vessels from preexisting ones through creation of new vesse...
We used a 3D in-vitro model of angiogenesis to investigate the effects of different growth factors o...
<div><p>Vascular endothelial growth factor (VEGF) plays a dominant role in angiogenesis. While inhib...
Transforming growth factor-beta 1 (TGF-beta 1) has been implicated in the positive regulation of ang...
Although the existence of an increasing number of angiogenesis-regulating cytokines is well document...
Endothelial cells plated on two-dimensional (2-D) substrata proliferate until they form a tightly ap...
Tightly controlled proteolytic degradation of the extracellular matrix by invading microvascular end...
To delineate potential angiogenic roles of platelet-derived growth factor (PDGF), we have investigat...
Abstract Background Sprouting angiogenesis requires v...
Alpha-smooth muscle actin is considered a reliable marker for distinguishing between arterial smooth...
Reciprocal plasticity exists between endothelial and mesenchymal lineages. For instance, mature endo...
Abstract Background Sprouting ...
Contains fulltext : 57438.pdf (publisher's version ) (Closed access)Background. An...
International audienceCytoskeletal rearrangements are central to endothelial cell physiology and are...
Transforming growth factor beta (TGF-beta) and its signaling mediators play essential roles in angio...
Angiogenesis, the formation of new blood vessels from preexisting ones through creation of new vesse...
We used a 3D in-vitro model of angiogenesis to investigate the effects of different growth factors o...
<div><p>Vascular endothelial growth factor (VEGF) plays a dominant role in angiogenesis. While inhib...
Transforming growth factor-beta 1 (TGF-beta 1) has been implicated in the positive regulation of ang...
Although the existence of an increasing number of angiogenesis-regulating cytokines is well document...
Endothelial cells plated on two-dimensional (2-D) substrata proliferate until they form a tightly ap...
Tightly controlled proteolytic degradation of the extracellular matrix by invading microvascular end...
To delineate potential angiogenic roles of platelet-derived growth factor (PDGF), we have investigat...
Abstract Background Sprouting angiogenesis requires v...
Alpha-smooth muscle actin is considered a reliable marker for distinguishing between arterial smooth...
Reciprocal plasticity exists between endothelial and mesenchymal lineages. For instance, mature endo...
Abstract Background Sprouting ...
Contains fulltext : 57438.pdf (publisher's version ) (Closed access)Background. An...
International audienceCytoskeletal rearrangements are central to endothelial cell physiology and are...
Transforming growth factor beta (TGF-beta) and its signaling mediators play essential roles in angio...
Angiogenesis, the formation of new blood vessels from preexisting ones through creation of new vesse...
We used a 3D in-vitro model of angiogenesis to investigate the effects of different growth factors o...
<div><p>Vascular endothelial growth factor (VEGF) plays a dominant role in angiogenesis. While inhib...