Previous studies from our laboratory have demonstrated that both chronic inflammatory pain, induced by intraplantar injection of complete Freund's adjuvant (CFA), and prolonged (48 h) stimulation of mu-opioid receptors (muOR) by systemic administration of a variety of selective agonists, resulted in enhanced plasma membrane targeting of delta-opioid receptors (deltaOR) in neurons of the dorsal spinal cord. To determine whether deltaOR trafficking induced by chronic inflammation was dependent on the activation of muOR, we investigated by immunogold cytochemistry the effects of intraplantar CFA injection on the plasma membrane density of deltaOR in muOR knockout (KO) mice. In untreated wild-type (WT) mice, only a small proportion of deltaOR w...
Previous studies have demonstrated that prolonged morphine treatment in vivo induces the translocati...
Numerous studies have demonstrated a physiological interaction between the mu opioid receptor (MOR) ...
Release of endogenous dynorphin opioids within the spinal cord after partial sciatic nerve ligation ...
Previous studies from our laboratory have demonstrated that both chronic inflammatory pain, induced ...
We recently demonstrated that prolonged treatment with morphine increases the antinociceptive potenc...
Pharmacological and physiological evidence supports a role for delta (delta) opioid receptors in the...
Opioid drugs acting at the mu opioid receptor (muOR), such as morphine, represent the most commonly...
International audienceTo examine the involvement of opioid receptors in inflammatory pain, we compar...
Opioid receptors are known to undergo complex regulatory changes in response to ligand exposure. In ...
Abstract Background Opioid receptors regulate a diverse array of physiological functions. Mu opioid ...
It is not clear whether primary afferent neurons express functional cell-surface opioid receptors. W...
We previously showed that prolonged morphine treatment and chronic inflammation both enhanced delta ...
Previous pharmacological studies have indicated the possible existence of functional interactions be...
GPCRs regulate a remarkable diversity of biological functions, and are thus often targeted for drug ...
Neuropathic pain is a debilitating chronic disease often resulting from damage to peripheral nerves....
Previous studies have demonstrated that prolonged morphine treatment in vivo induces the translocati...
Numerous studies have demonstrated a physiological interaction between the mu opioid receptor (MOR) ...
Release of endogenous dynorphin opioids within the spinal cord after partial sciatic nerve ligation ...
Previous studies from our laboratory have demonstrated that both chronic inflammatory pain, induced ...
We recently demonstrated that prolonged treatment with morphine increases the antinociceptive potenc...
Pharmacological and physiological evidence supports a role for delta (delta) opioid receptors in the...
Opioid drugs acting at the mu opioid receptor (muOR), such as morphine, represent the most commonly...
International audienceTo examine the involvement of opioid receptors in inflammatory pain, we compar...
Opioid receptors are known to undergo complex regulatory changes in response to ligand exposure. In ...
Abstract Background Opioid receptors regulate a diverse array of physiological functions. Mu opioid ...
It is not clear whether primary afferent neurons express functional cell-surface opioid receptors. W...
We previously showed that prolonged morphine treatment and chronic inflammation both enhanced delta ...
Previous pharmacological studies have indicated the possible existence of functional interactions be...
GPCRs regulate a remarkable diversity of biological functions, and are thus often targeted for drug ...
Neuropathic pain is a debilitating chronic disease often resulting from damage to peripheral nerves....
Previous studies have demonstrated that prolonged morphine treatment in vivo induces the translocati...
Numerous studies have demonstrated a physiological interaction between the mu opioid receptor (MOR) ...
Release of endogenous dynorphin opioids within the spinal cord after partial sciatic nerve ligation ...