This dissertation has three primary aims. The first is to offer a new perspective on the philosophical world view of Ernst Mach, and in particular on his well-known doctrine of elements. This is achieved primarily within a historical context, specifically by exposing two misrepresentations of Mach's thought framed by two of his most famous detractors, Vladimir Lenin and Max Planck. Contrary to their claims that Mach was either a reactionary idealist or a solipsistic positivist, I argue that Mach's philosophical standpoint is best described as a biological empiricism. This re-constructed position is developed throughout the text as the one that best captures the variety of roles actually played by the doctrine of elements within Mach's philo...