The innate immune system can detect the presence of microbial infection by employing germline-encoded receptors specific for conserved microbial ligands. For example, the extracellular presence of the bacterial protein flagellin is sensed by Toll-like receptor 5, leading to activation of the transcription factor NF-κB, cytokine expression, and immune responses. In addition, certain flagellated bacterial pathogens, also appear to be sensed by an inflammasome. The inflammasome is a cytosolic molecular complex that contains a host Nod-like protein, Ipaf, and triggers caspase-1 and macrophage death. We used the intracellular pathogen Legionella pneumophila as a model intracellular bacterium to study the activation of the Ipaf inflammasome. Mac...
Motile bacteria synthesize large-sized surface structures known as flagella through the ordered poly...
Motile bacteria synthesize large-sized surface structures known as flagella through the ordered poly...
The causative agent of Legionnaires’ disease is L. pneumophila, an intracellular pathogen that infec...
Macrophages respond to Salmonella typhimurium infection via Ipaf, a NACHT–leucine-rich repeat family...
To restrict infection by Legionella pneumophila, mouse macrophages require Naip5, a member of the nu...
To restrict infection by Legionella pneumophila, mouse macrophages require Naip5, a member of the nu...
The mucosal surfaces of metazoan organisms provide niches for colonization by commensal microbes. Ho...
The mucosal surfaces of metazoan organisms provide niches for colonization by commensal microbes. Ho...
Thesis (Ph.D.)--University of Washington, 2013Salmonella enterica serovar Typhimurium is a flagellat...
Flagellin is recognized by both Toll-like receptor (TLR)5 and NAIP5/NLRC4 inflammasome receptors. We...
Thesis (Ph.D.)--University of Washington, 2014Within this dissertation, we have determined how compo...
Thesis (Ph.D.)--University of Washington, 2014Within this dissertation, we have determined how compo...
Salmonella enterica serovar Typhimurium is a flagellated bacterium and one of the leading causes of ...
The Gram-negative bacterium Legionella pneumophila colonizes extracellular environmental niches and ...
The causative agent of Legionnaires’ disease is L. pneumophila, an intracellular pathogen that infec...
Motile bacteria synthesize large-sized surface structures known as flagella through the ordered poly...
Motile bacteria synthesize large-sized surface structures known as flagella through the ordered poly...
The causative agent of Legionnaires’ disease is L. pneumophila, an intracellular pathogen that infec...
Macrophages respond to Salmonella typhimurium infection via Ipaf, a NACHT–leucine-rich repeat family...
To restrict infection by Legionella pneumophila, mouse macrophages require Naip5, a member of the nu...
To restrict infection by Legionella pneumophila, mouse macrophages require Naip5, a member of the nu...
The mucosal surfaces of metazoan organisms provide niches for colonization by commensal microbes. Ho...
The mucosal surfaces of metazoan organisms provide niches for colonization by commensal microbes. Ho...
Thesis (Ph.D.)--University of Washington, 2013Salmonella enterica serovar Typhimurium is a flagellat...
Flagellin is recognized by both Toll-like receptor (TLR)5 and NAIP5/NLRC4 inflammasome receptors. We...
Thesis (Ph.D.)--University of Washington, 2014Within this dissertation, we have determined how compo...
Thesis (Ph.D.)--University of Washington, 2014Within this dissertation, we have determined how compo...
Salmonella enterica serovar Typhimurium is a flagellated bacterium and one of the leading causes of ...
The Gram-negative bacterium Legionella pneumophila colonizes extracellular environmental niches and ...
The causative agent of Legionnaires’ disease is L. pneumophila, an intracellular pathogen that infec...
Motile bacteria synthesize large-sized surface structures known as flagella through the ordered poly...
Motile bacteria synthesize large-sized surface structures known as flagella through the ordered poly...
The causative agent of Legionnaires’ disease is L. pneumophila, an intracellular pathogen that infec...